- Gastric Cancer and DNA Mismatch Repair
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Kim JJ, Park DI
- KMID: 1598593
- Korean J Gastroenterol.
- 2001 Apr;37(4):233-239.
Cancer developes when mutations accumulate in key growth-regulating genes. The two classes of genes implicated in this malignant transformation are designated oncogenes and tumor-suppressor genes. Recently, a new class of... -
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- Expression Pattern of DNA Mismatch Repair Genes in Tumors of Microsatellite Mutator Phenotype
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Kim JJ, Baek MJ, Kim NG, Kim YH, Kim JE, Kim H, Park C
- KMID: 1725720
- Korean J Pathol.
- 2000 Sep;34(9):609-614.
Microsatellite mutator phenotype (MMP) tumors were reported in a subset of gastrointestinal carcinomas. The molecular pathogenesis of MMP tumors shows defects in the DNA mismatch repair genes, and also many... -
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- A Case of Muir-Torre Syndrome: Extra-ocular Sebaceous Carcinoma in a Patient with Breast Cancer
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Kim MS, Park OJ, Won CH, Chang SE, Lee MW, Choi JH, Moon KC
- KMID: 2301851
- Korean J Dermatol.
- 2010 Aug;48(8):696-699.
Muir-Torre syndrome is defined by concurrent or sequential development of internal malignancy - most commonly colorectal cancer - and sebaceous neoplasm or multiple keratoacanthomas. Recent studies revealed it was caused... -
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- The Effect of Genetic Variation in The Dna Base Repair Genes on the Risk of Head and Neck Cancer
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Oh JH, Yoon BW, Choi BJ
- KMID: 2005382
- J Korean Assoc Oral Maxillofac Surg.
- 2008 Oct;34(5):509-517.
DNA damage accumulates in cells as a result of exposure to exogenous agents such as benzopyrene, cigarette smoke, ultraviolet light, X-ray, and endogenous chemicals including reactive oxygen species produced from... -
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- Hereditary Nonpolyposis Colorectal Cancer
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Oh BY
- KMID: 2367894
- Ewha Med J.
- 2017 Jan;40(1):29-34.
- doi: 10.12771/emj.2017.40.1.29
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common hereditary colorectal cancer syndrome and accounts for about 5% of colorectal cancer. It is inherited as autosomal dominant type and is... -
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- Loss of ARID1A Expression in Gastric Cancer: Correlation with Mismatch Repair Deficiency and Clinicopathologic Features
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Kim KJ, Jung HY, Oh MH, Cho H, Lee JH, Lee HJ, Jang SH, Lee MS
- KMID: 2372206
- J Gastric Cancer.
- 2015 Sep;15(3):201-208.
- doi: 10.5230/jgc.2015.15.3.201
PURPOSE: The AT-rich interactive domain 1A (ARID1A) gene encodes BRG1-associated factor 250a, a component of the SWItch/Sucrose NonFermentable chromatin remodeling complex, which is considered a tumor suppressor in many tumors.... -
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- Radiotherapy Response in Microsatellite Instability Related Rectal Cancer
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Shin JS, Tut TG, Yang T, Lee CS
- KMID: 1837564
- Korean J Pathol.
- 2013 Feb;47(1):1-8.
Preoperative radiotherapy may improve the resectability and subsequent local control of rectal cancers. However, the extent of radiation induced regression in these tumours varies widely between individuals. To date no... -
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- Prognostic Significance of Immunohistochemical MSH2 Expression in Prostate Cancer
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Kim YB, Lee DG, Yoo KH, Lee HL, Choi SK
- KMID: 2438595
- Korean J Urol Oncol.
- 2018 Aug;16(2):58-62.
- doi: 10.22465/kjuo.2018.16.2.58
PURPOSE: There are numerous prostate cancer-related genes that involve in carcinogenesis and tumor progression. Among the genes, DNA mismatch repair genes recognize and repair misincorporated nucleotides during DNA replication. In... -
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- Hereditary Colon Cancer: Lynch Syndrome
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Jang E, Chung DC
- KMID: 2284180
- Gut Liver.
- 2010 Jun;4(2):151-160.
Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is... -
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- One case of Lynch type II syndrome
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Kim K, Kim NE, Lee Y, Kim K, Hong S, Baek S, Joo M
- KMID: 2273803
- Korean J Obstet Gynecol.
- 2009 Nov;52(11):1164-1168.
Lynch syndrome is also called Hereditary nonpolyposis colorectal cancer (HNPCC). It is characterized by a risk of colorectal cancer and other cancers of the endometrium, ovary, stomach, small intestine etc.... -
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- Expression of hMSH2, hMLH1 Protein in Sporadic Colorectal Cancer and Corresponding Normal Tissue
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Jung JY, Park DK, Shin JH
- KMID: 1835109
- J Korean Soc Coloproctol.
- 1998 Dec;14(4):709-718.
PURPOSE: DNA mismatch repair gene is responsible for hereditary nonpolyposis colorectal cancer. But it is not well known its role in sporadic colorectal cancer patients. We analysed normal hMSH2, hMLH1... -
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- Mutation of DNA Mismatch Repair Genes and its Relation to Taxol and Topotecan Chemosensitivity in the Clones from the Cisplatin-Resistant Ovarian Cancer Cell Lines
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Kim HK, Son WS, Park TC, Kim TE, Koh YM, Song JM, Park KY, Kim JH, Ryu KS, Kim JW, NamKoong S, Kim SP
- KMID: 2075936
- Korean J Obstet Gynecol.
- 1999 Nov;42(11):2465-2473.
OBJECTIVE: Ovarian cancer represents a relatively chemosensitive solid tumor, with responsiveness to a range of agents. Cisplatin is the mainstay of drug treatment and is one of the most active... -
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- Suppressed DNA Repair Mechanisms in Rheumatoid Arthritis
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Lee SH, Firestein
- KMID: 1974519
- Immune Netw.
- 2002 Dec;2(4):208-216.
- doi: 10.4110/in.2002.2.4.208
BACKGROUND: Reactive oxygen and nitrogen are produced by rheumatoid arthritis (RA) synovial tissue and can induce mutations in key genes. Normally, this process is prevented by a DNA mismatch repair... -
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- BRCA1-mutated ovarian cancer with skin metastasis: a case report
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Oh SR, Park JW, Kwon HY, Rha SH
- KMID: 2393849
- Obstet Gynecol Sci.
- 2017 Sep;60(5):477-480.
- doi: 10.5468/ogs.2017.60.5.477
The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies... -
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- Identification of Target Genes in the Endometrial Carcinomas with Microsatellite Mutator Phenotype
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You KT, Kim H, Park TK, Sohn IS, Lee JY, Jang DW, Yang WG, Kim SN
- KMID: 2272602
- Korean J Obstet Gynecol.
- 2005 May;48(5):1229-1240.
OBJECTIVE: Recent molecular genetic studies have revealed that two major types of genomic instabilities, chromosomal instability and microsatellite instability (MSI), exist in the endometrial carcinomas. Tumors with microsatellite mutator phenotype... -
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- DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers
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Kato M, Takano M, Miyamoto M, Sasaki N, Goto T, Tsuda H, Furuya K
- KMID: 2158801
- J Gynecol Oncol.
- 2015 Jan;26(1):40-45.
- doi: 10.3802/jgo.2015.26.1.40
OBJECTIVE: Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not... -
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- Analysis of Microsatellite Instability and Loss of Heterozygosity in Sporadic Keratoacanthoma
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Ha TW, Han KH, Kim DK
- KMID: 2030772
- Korean J Anat.
- 2005 Feb;38(1):55-61.
Tumors from patients with hereditary non-polyposis colorectal cancer (HNPCC)and from a subset of patients with the related Muir-Torre syndrome exhibit a type of a genetic instability, known as microsatellite instability... -
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- Clinical significance of mismatch repair genes immunohistochemical expression of complex endometrial hyperplasia
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Han SJ, Kim MK
- KMID: 2314033
- Obstet Gynecol Sci.
- 2015 Mar;58(2):106-111.
- doi: 10.5468/ogs.2015.58.2.106
OBJECTIVE: Women with Lynch syndrome have an increased risk of developing colorectal and gynecologic malignancies such as endometrial cancer. Complex hyperplasia has about a 30% risk of developing into endometrial... -
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- Interactome Analysis Reveals that Heterochromatin Protein 1gamma (HP1gamma) Is Associated with the DNA Damage Response Pathway
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Kim H, Choi JD, Kim BG, Kang HC, Lee JS
- KMID: 2152291
- Cancer Res Treat.
- 2016 Jan;48(1):322-333.
- doi: 10.4143/crt.2014.294
PURPOSE: Heterochromatin protein 1gamma (HP1gamma) interacts with chromosomes by binding to lysine 9-methylated histone H3 or DNA/RNA. HP1gamma is involved in various biological processes. The purpose of this study is... -
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- Microsatellite Instability and Mismatch Repair Protein (hMLH1, hMSH2) Expression in Intrahepatic Cholangiocarcinoma
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Kang YK, Kim WH
- KMID: 2275436
- Korean J Pathol.
- 2005 Feb;39(1):9-14.
BACKGROUND: To clarify the role of the mismatch repair (MMR) system in the carcinogenesis of intrahepatic cholangiocarcinoma (ICC), we investigated the microsatellite instability (MSI) status and MMR protein expression in... -
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