- β-Catenin Regulates the Expression of cAMP Response Element-Binding Protein 1 in Squamous Cell Carcinoma Cells
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Kim SY, Lee JH, Sohn KC, Im M, Lee Y, Seo YJ, Lee JH, Kim CD
- KMID: 2399775
- Ann Dermatol.
- 2018 Feb;30(1):119-122.
- doi: 10.5021/ad.2018.30.1.119
No abstract available. -
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- Neurobiological Mechanism of Memory
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Chung YI, Lee YM, Moon ES
- KMID: 2186118
- J Korean Geriatr Psychiatry.
- 2016 Apr;20(1):1-8.
- doi: 10.0000/jkgp.2016.20.1.1
Memory is one of the most important mental mechanisms which is crucial for us to adapt to environmental surroundings and to maintain our identity. The neurobiological mechanisms for memory are... -
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- Striatal CREB Phosphorylation Following Cued/Response Learning in the Water Maze Differ in Two Inbred Strains of Mice
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Hwang YK, Han JS
- KMID: 2165281
- Exp Neurobiol.
- 2008 Dec;17(2):41-46.
- doi: 10.5607/en.2008.17.2.41
Much evidence shows that the hippocampus and striatum play roles as important neural substrates for spatial/place and cued/response learning, respectively. This experiment was conducted to investigate the engagement of the... -
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- Effects of dopamine and haloperidol on morphine-induced CREB and AP-1 DNA binding activities in differentiated SH-SY5Y human neuroblastoma cells
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Kim SK, Kwon GY
- KMID: 2071825
- Korean J Physiol Pharmacol.
- 1998 Dec;2(6):671-676.
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects... -
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- Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis
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Matsuda-Hirose H, Yamate T, Goto M, Katoh A, Kouji H, Yamamoto Y, Sakai T, Uemura N, Kobayashi , Hatano Y
- KMID: 2461985
- Ann Dermatol.
- 2019 Dec;31(6):631-639.
- doi: 10.5021/ad.2019.31.6.631
BACKGROUND: The canonical Wnt/β-catenin signaling pathway is a fundamental regulatory system involved in various biological events. ICG-001 selectively blocks the interaction of β-catenin with its transcriptional co-activator cyclic AMP response... -
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- A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP
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Kida S
- KMID: 2165411
- Exp Neurobiol.
- 2012 Dec;21(4):136-140.
- doi: 10.5607/en.2012.21.4.136
cAMP response element-binding protein (CREB), a transcription factor, has been shown to play a central role in memory formation, and its involvement in this process has been investigated using a... -
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- cAMP/PKA Agonist Restores the Fasting-Induced Down-Regulation of nNOS Expression in the Paraventricular Nucleus
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Yoo SB, Lee S, Lee JY, Kim BT, Lee JH, Jahng JW
- KMID: 1493966
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):333-337.
- doi: 10.4196/kjpp.2012.16.5.333
Gene expression of neuronal nitric oxide synthase (nNOS) changes in the hypothalamic paraventricular nucleus (PVN) depending on feeding conditions, which is decreased during food deprivation and restored by refeeding, and... -
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- Administration of Phytoceramide Enhances Memory and Upregulates the Expression of pCREB and BDNF in Hippocampus of Mice
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Lee Y, Kim J, Jang S, Oh S
- KMID: 1502492
- Biomol Ther.
- 2013 May;21(3):229-233.
This study was aimed at investigating the possible effects of phytoceramide (Pcer) on learning and memory and their underlying mechanisms. Phytoceramide was orally administered to ICR mice for 7 days.... -
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- Regulation of phosphorylated cAMP response element-binding protein, Fos-related antigen and FosB expression by dopamine agonists in rat striatum
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Choe ES, Kim JY
- KMID: 2071569
- Korean J Physiol Pharmacol.
- 2001 Aug;5(4):299-305.
Activation of D1-like dopamine receptors by psychostimulants, such as amphetamine, upregulates the expression of immediate early gene and opioid peptide gene in the striatum. The genomic changes are regulated by phosphorylated transcription factors... -
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- Transcriptional Mechanisms of Drug Addiction
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Nestler EJ
- KMID: 1432535
- Clin Psychopharmacol Neurosci.
- 2012 Dec;10(3):136-143.
- doi: 10.9758/cpn.2012.10.3.136
Regulation of gene expression is considered a plausible mechanism of drug addiction given the stability of behavioral abnormalities that define an addicted state. Numerous transcription factors, proteins that bind to... -
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- Downstream molecular events in the altered profiles of lysophosphatidic acid-induced cAMP in senescent human diploid fibroblasts
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Jang IS, Rhim JH, Park SC, Yeo EJ
- KMID: 1111406
- Exp Mol Med.
- 2006 Apr;38(2):134-143.
Lysophosphatidic acid (LPA) is a phospholipid growth factor that acts through G-protein-coupled receptors. Previously, we demonstrated an altered profile of LPA-dependent cAMP content during the aging process of human diploid... -
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- Wogonin Attenuates Hippocampal Neuronal Loss and Cognitive Dysfunction in Trimethyltin-Intoxicated Rats
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Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2164226
- Biomol Ther.
- 2016 May;24(3):328-337.
- doi: 10.4062/biomolther.2015.152
We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these... -
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- Cilostazol attenuates kainic acid-induced hippocampal cell death
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Park YS, Jin Z, Jeong EA, Yi CO, Lee JY, Park IS, Roh GS
- KMID: 2398556
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):63-70.
- doi: 10.4196/kjpp.2018.22.1.63
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate... -
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- Signal Transduction Related Oncogenes in Human Adrenal Cortical Tumor; Gsα Giα, CREB
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Lee EJ, Kim KR, Lee HC, Huh KB, Lim SK, Jung EK, Park HC, Jung WH, Shin DW, Lee HS, Yoon YD
- KMID: 2461530
- J Korean Soc Endocrinol.
- 1994 Dec;9(4):350-357.
Functioning adrenal cortical tumors are originated form a distinct zone(zonna glomerulosa, zonna fasciculata or zonna reticularis) or the transitonal zone of adrenal gland. Each zone of the gland is regulated... -
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- Scopoletin from Cirsium setidens Increases Melanin Synthesis via CREB Phosphorylation in B16F10 Cells
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Ahn MJ, Hur SJ, Kim EH, Lee SH, Shin JS, Kim MK, Uchizono J, Whang WK, Kim DS
- KMID: 2285524
- Korean J Physiol Pharmacol.
- 2014 Aug;18(4):307-311.
- doi: 10.4196/kjpp.2014.18.4.307
In this study, we isolated scopoletin from Cirsium setidens Nakai (Compositae) and tested its effects on melanogenesis. Scopoletin was not toxic to cells at concentrations less than 50 microM and... -
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- Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase
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Lee HE, Kim EH, Choi HR, Sohn UD, Yun HY, Baek KJ, Kwon NS, Park KC, Kim DS
- KMID: 2011164
- Korean J Physiol Pharmacol.
- 2012 Aug;16(4):287-291.
- doi: 10.4196/kjpp.2012.16.4.287
This study investigated the effects of proline-serine (PS) and valine-serine (VS) dipeptides on melanogenesis in Mel-Ab cells. Proline-serine and VS significantly inhibited melanin synthesis in a concentration-dependent manner, though neither... -
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- Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models
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Kim Y, Kwon SY, Jung HS, Park YJ, Kim YS, In JH, Choi JW, Kim JA, Joo JD
- KMID: 2438623
- Korean J Anesthesiol.
- 2019 Feb;72(1):60-67.
- doi: 10.4097/kja.d.18.00022
BACKGROUND: The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline. The A3 adenosine receptor... -
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- MSK1 regulates RANKL-induced NFATc1 expression through CREB and c-Fos
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Ha J, Hwang JH, Kwon SG, Park DH, Kim TW, Kang DG, Kang KH, Kim IS, Kim CW
- KMID: 2286279
- J Biomed Res.
- 2015 Jun;16(2):35-39.
- doi: 10.12729/jbr.2015.16.2.035
Osteoclasts originated from hematopoietic stem cells are multi-nucleated cells that can resorb the bone matrix. Receptor activator of nuclear factor kappa-B (RANK)/RANK ligand (RANKL) signaling pathway is crucial for the... -
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- Differential Histone Acetylation in Sub-Regions of Bed Nucleus of the Stria Terminalis Underlies Fear Consolidation and Extinction
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Ranjan V, Singh S, Siddiqui S, Tripathi S, Khan MY, Prakash A
- KMID: 2378651
- Psychiatry Investig.
- 2017 May;14(3):350-359.
- doi: 10.4306/pi.2017.14.3.350
OBJECTIVE: The hallmark of anxiety disorders is excessive fear. Previous studies have suggested that selective neural projections from Basal nucleus of stria terminalis (BNST) to amygdala and vice-versa precisely control... -
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- Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
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Lee SE, Park HR, Jeon S, Han D, Park YS
- KMID: 2470810
- J Lipid Atheroscler.
- 2020 Jan;9(1):184-194.
- doi: 10.12997/jla.2020.9.1.184
OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via... -
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