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Relaxin Modulates the Expression of MMPs and TIMPs in Fibroblasts of Patients with Carpal Tunnel Syndrome

Kang YM, Lee HM, Moon SH, Kang H, Choi YR

PURPOSE: The aim of this study was to investigate the anti-fibrotic effect of relaxin in subsynovial fibroblasts activated by transforming growth factor beta (TGF-β). MATERIALS AND METHODS: To test the anti-fibrotic...
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The Inhibitory Effect of siRNAs on The High Glucose-Induced Overexpression of TGF-beta1 in Mesangial Cells

Noh HJ, Kim HC, Lee SS, Kang YN, Chae YM, Park KK

Diabetic nephropathy is characterized by an expansion of the glomerular mesangium, caused by mesangial cell proliferation and an excessive accumulation of extracellar matrix (ECM) proteins, which eventually leading to glomerulosclerosis....
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Changes in Bone Metabolism in Young Castrated Male Rats

Ryu SJ, Ryu DS, Kim JY, Park JY, Kim KH, Chin DK, Kim KS, Cho YE, Kuh SU

PURPOSE: To determine the window of time during which osteoporosis affects the management of spinal surgery and the mechanism of bone metabolism changes in males with osteoporosis by examining changes...
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Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates

Lee YJ, Jeong JK, Seol JW, Xue M, Jackson C, Park SY

  • KMID: 2154228
  • Exp Mol Med.
  • 2013 Feb;45(2):e9.
Activated protein C (APC) is a cytoprotective anticoagulant that can promote cutaneous healing. We examined the effect of APC on viability and differentiation of the osteoblastic line, MG63, in the...
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Bone Mineral Density, Biochemical Bone Turnover Markers and Factors associated with Bone Health in Young Korean Women

Park YJ, Lee SJ, Shin NM, Shin H, Kim YK, Cho Y, Jeon S, Cho I

PURPOSE: This study was done to assess the bone mineral density (BMD), biochemical bone turnover markers (BTMs), and factors associated with bone health in young Korean women. METHODS: Participants were 1,298...
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HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1

Shin JY, Hur W, Wang JS, Jang JW, Kim CW, Bae SH, Jang SK, Yang SH, Sung YC, Kwon OJ, Yoon SK

  • KMID: 755753
  • Exp Mol Med.
  • 2005 Apr;37(2):138-145.
Liver cirrhosis is one of the major complications of hepatitis C virus (HCV) infection, but the mechanisms underlying HCV-related fibrogenesis are still not clear. Although the roles of HCV core...
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