- Acetylcholinesterase Inhibitors from Angelica polymorpha Stem
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Kwon Y, Kim HP, Kim MJ, Chun W
- KMID: 2387058
- Nat Prod Sci.
- 2017 Jun;23(2):97-102.
- doi: 10.20307/nps.2017.23.2.97
Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin... -
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- Topical Hypopigmenting Agents for Pigmentary Disorders and Their Mechanisms of Action
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Kim H, Choi HR, Kim DS, Park KC
- KMID: 2156847
- Ann Dermatol.
- 2012 Feb;24(1):1-6.
- doi: 10.5021/ad.2012.24.1.1
Melanin is produced in melanocytes and stored in melanosomes. In spite of its beneficial sun-protective effect, abnormal accumulation of melanin results in esthetic problems. Hydroquinone, competing with tyrosine, is a... -
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- Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models
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Park MY, Kwon HJ, Sung MK
- KMID: 2313371
- Nutr Res Pract.
- 2009 Mar;3(1):9-14.
Aloe products are one of the top selling health-functional foods in Korea, however the adequate level of intake to achieve desirable effects are not well understood. The objective of this... -
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- Induction Mechanism of PD-L1 (Programmed Cell Death-ligand 1) in Sepsis
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Lee SM
- KMID: 2319096
- Tuberc Respir Dis.
- 2008 Oct;65(4):343-350.
PD-L1 is expressed in a variety of antigen-presenting cells and provides T cell tolerance via ligation with its receptor PD-1 and B7-1 on T cells. Stimulation with lipopolysaccharide (LPS) can... -
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- A Case of Chronic Urticaria Presenting with Double Primary Malignancies in the Stomach and the Colon
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- KMID: 2299567
- Korean J Asthma Allergy Clin Immunol.
- 2009 Sep;29(3):208-211.
Chronic urticaria is a common disabling skin condition. Neoplasm has been case-reported as a comorbid disease with urticaria, although there is no reliable evidence suggesting a strong association between these... -
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- Composition of Flavonoids and Antioxidative Activity from Juice of Jeju Native Citrus Fruits during Maturation
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Kim YD, Ko WJ, Koh KS, Jeon YJ, Kim SH
- KMID: 2264727
- Korean J Nutr.
- 2009 Apr;42(3):278-290.
- doi: 10.4163/kjn.2009.42.3.278
This study aims to evaluate the changes of flavonoid contents and antioxidants activity of Jeju native citrus fruits juice according to the harvest date. Flavonoids such as quercatagetin, narirutin, hesperidin... -
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- Genotype and clinical features of Korean patients with methylmalonic aciduria and propionic aciduria
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Lee EH, Ko JM, Kim JM, Yoo HW
- KMID: 2280191
- Korean J Pediatr.
- 2008 Sep;51(9):964-970.
- doi: 10.3345/kjp.2008.51.9.964
PURPOSE: Methylmalonic aciduria (MMA) and propionic aciduria (PA) are inborn errors in the catabolism of branched-chain amino acids. The study was undertaken to investigate the genotypes and clinical features of... -
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- Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1beta in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages
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Won K, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K
- KMID: 2285454
- Korean J Physiol Pharmacol.
- 2012 Dec;16(6):447-453.
- doi: 10.4196/kjpp.2012.16.6.447
TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to... -
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- Induction of Melanogenesis by Rapamycin in Human MNT-1 Melanoma Cells
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Hah YS, Cho HY, Lim TY, Park DH, Kim HM, Yoon J, Kim JG, Kim CY, Yoon TJ
- KMID: 2434679
- Ann Dermatol.
- 2012 May;24(2):151-157.
BACKGROUND: Melanogenesis is one of the characteristic parameters of differentiation in melanocytes and melanoma cells. Specific inhibitors of phosphatidylinositol 3-kinase (PI3K), such as wortmannin and LY294002, stimulate melanin production in... -
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- Insulin Like Growth Factor Binding Protein-5 Regulates Excessive Vascular Smooth Muscle Cell Proliferation in Spontaneously Hypertensive Rats via ERK 1/2 Phosphorylation
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Lee DH, Kim JE, Kang YJ
- KMID: 1429387
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):157-162.
- doi: 10.4196/kjpp.2013.17.2.157
Insulin-like growth factor binding proteins (IGFBPs) are important components of insulin growth factor (IGF) signaling pathways. One of the binding proteins, IGFBP-5, enhances the actions of IGF-1, which include the... -
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- Extracellular Nucleotides Can Induce Chemokine (C-C motif) Ligand 2 Expression in Human Vascular Smooth Muscle Cells
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Kim JI, Kim HY, Kim SM, Lee SA, Son YH, Eo SK, Rhim BY, Kim K
- KMID: 2389106
- Korean J Physiol Pharmacol.
- 2011 Feb;15(1):31-36.
To understand the roles of purinergic receptors and cellular molecules below the receptors in the vascular inflammatory response, we determined if extracellular nucleotides up-regulated chemokine expression in vascular smooth muscle... -
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- Induction of Inducible Nitric Oxide Synthase Expression by Manganese in C6 Glioma Cells
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Yu GI, Lee DH, Chung IS, Lee MY, Shin DH
- KMID: 1475121
- Korean J Occup Environ Med.
- 2009 Sep;21(3):259-266.
OBJECTIVE: It is well established that manganese neurotoxicity is associated with clinical symptoms similar to those of idiopathic Parkinson's disease. Recent research has shown that the exposure to manganese (MnCl2)... -
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- Effects of alpha-lipoic Acid on Differentiation of Thyroid Cancer Cells
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Kim WG, Han DH, Choi HJ, Kim EY, Kim TY, Shong YK, Kim WB
- KMID: 2177858
- J Korean Endocr Soc.
- 2010 Mar;25(1):28-36.
- doi: 10.3803/jkes.2010.25.1.28
BACKGROUND: Induction of re-differentiation is necessary for the proper treatment of patients with recurrent or metastatic differentiated thyroid cancer (DTC) because cancer cells show de-differentiation in about 30% of these... -
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- Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation
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Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW
- KMID: 2363495
- J Korean Med Sci.
- 2016 Mar;31(3):360-370.
- doi: 10.3346/jkms.2016.31.3.360
Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after... -
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- Midazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injury
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Chong WS, Hyun CL, Park MK, Park JM, Song HO, Park T, Lim YS, Cho CK, Kang PS, Kwon HU
- KMID: 2236297
- Korean J Anesthesiol.
- 2012 Feb;62(2):166-171.
- doi: 10.4097/kjae.2012.62.2.166
BACKGROUND: Soman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as... -
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- Reactive Oxygen Species Generated by 17beta-estradiol Play a Role in the Up-regulation of GPX4 Protein in MCF-7 Breast Cancer Cells
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Lee SH, Kim HJ, Kang HJ, Lee YJ, Nam HS, Bae I
- KMID: 2242003
- J Breast Cancer.
- 2009 Sep;12(3):134-141.
- doi: 10.4048/jbc.2009.12.3.134
PURPOSE: Estrogen is known to act as both a growth factor and a survival factor for breast cancer. The responsible molecular mechanisms remain, however, to be fully elucidated. We hypothesize... -
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- Phenylpropanoids in radioregulation: double edged sword
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Kim W, Seong KM, Youn B
- KMID: 1107373
- Exp Mol Med.
- 2011 Jun;43(6):323-333.
- doi: 10.3858/emm.2011.43.6.034
Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals... -
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- Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells
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Oh SY, Park KS, Kim AJ, Choi KY
- KMID: 1093594
- Exp Mol Med.
- 2002 Mar;34(1):27-31.
Activation of the extra cellular signal regulated kinase (ERK) pathway is involved in both proliferation and growth arrest of cells depending on intensity and duration of stimuli. In this study,... -
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- Rapid increase of cytosolic content of acetyl-CoA carboxylase isoforms in H9c2 cells by short-term treatment with insulin and okadaic acid
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Park CE, Ko SM, Kim JM, Yoon MY, Kim JY, Kang IS, Kim SS, Ha JH
- KMID: 754991
- Exp Mol Med.
- 1998 Jun;30(2):73-79.
Mammalian acetyl-CoA carboxylase (ACC) is present in two isoforms, alpha and beta, both of which catalyze formation of malonyl-CoA by fixing CO2 into acetyl-CoA. ACC-alpha is highly expressed in lipogenic tissues whereas... -
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- betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin
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Lee BH, Bae JS, Park RW, Kim JE, Park JY, Kim IS
- KMID: 1111408
- Exp Mol Med.
- 2006 Apr;38(2):153-161.
Adhesion and migration of vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of atherosclerosis. These processes involve the interaction of VSMCs with extracellular matrix proteins. Here,... -
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