- The Regulatory Effects of Trans-chalcone on Adipogenesis
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Han Y
- KMID: 2437482
- Int J Oral Biol.
- 2018 Mar;43(1):29-35.
- doi: 10.11620/IJOB.2018.43.1.029
It is noted that chalcone derivatives have characteristic diverse pharmacological properties, and that precise evidence has been growing that they could regulate a tumor necrosis factor-α (TNF-α) induced insulin resistance.... -
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- Antifungal Activity of 2-Hydroxy 4,4'6'Trimethoxy Chalcone
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Mishra PK, Sarma BK, Singhai PK, Singh UP
- KMID: 2383710
- Mycobiology.
- 2007 Jun;35(2):72-75.
Antifungal activity of 2-hydroxy 4,4'6'trimethoxy chalcone individually was tested against spore germination of ten fungi of different genera. Efficacy of the chemical was also tested against conidial germination and other... -
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- Nitric Oxide Inhibitory Constituents from the Fruits of Amomum tsao-ko
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Kim JG, Le TP, Hong HR, Han JS, Ko JH, Lee SH, Lee MK, Hwang BY
- KMID: 2443108
- Nat Prod Sci.
- 2019 Mar;25(1):76-80.
- doi: 10.20307/nps.2019.25.1.76
Bioactivity-guided fractionation of MeOH extract of the dried fruits of Amomum tsao-ko led to isolation of nine compounds (1 – 9). Their structures were elucidated by spectroscopic methods including extensive... -
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- Isoliquiritigenin, a Chalcone Compound, Enhances Spontaneous Inhibitory Postsynaptic Response
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Woo J, Cho S, Lee CJ
- KMID: 2165517
- Exp Neurobiol.
- 2014 Jun;23(2):163-168.
- doi: 10.5607/en.2014.23.2.163
Isoliquiritigenin (ILTG) is a chalcone compound and shows various pharmacological properties, including antioxidant and anti-inflammatory activities. In recent study, we have reported a novel role of ILTG in sleep through... -
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- YJI-7 Suppresses ROS Production and Expression of Inflammatory Mediators via Modulation of p38MAPK and JNK Signaling in RAW 264.7 Macrophages
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Oh HJ, Magar TB, Pun NT, Lee Y, Kim EH, Lee ES, Park PH
- KMID: 2429059
- Biomol Ther.
- 2018 Mar;26(2):191-200.
- doi: 10.4062/biomolther.2016.276
Chalcone, (2E)-1,3-Diphenylprop-2-en-1-one, and its synthetic derivatives are known to possess anti-oxidative and anti-inflammatory properties. In the present study, we prepared a novel synthetic chalcone compound, (E)-1-(4-hydroxyphenyl)-3-(2-(trifluoromethoxy)phenyl)prop-2-en-1-one name (YJI-7), and investigated... -
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- Induction of apoptosis in human cervical cancer cells by isoliquritizenin
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Jung SW, Kim YO, Kim SH, Kwon SH, Cho CH, Cha SD
- KMID: 2143526
- Korean J Gynecol Oncol.
- 2006 Mar;17(1):47-53.
OBJECTIVE: Isoliquritizenin (ISL) is a chalcone flavonoid, present in licorice, shallot and bean sprouts, has cancer preventing properties and often used in chinese medicine. In this study, ISL to determine... -
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- Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling
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Kim MJ, Kadayat T, Um YJ, Jeong TC, Lee ES, Park PH
- KMID: 2380344
- Biomol Ther.
- 2015 Mar;23(2):119-127.
- doi: 10.4062/biomolther.2014.127
Chalcones (1,3-diaryl-2-propen-1-ones), a subfamily of flavonoid, are widely known to possess potent anti-inflammatory and anti-oxidant properties. In this study, we investigated the effect of 3-(4-Hydroxyphenyl)-1-(thio3-(4-Hydroxyphenyl phen-2-yl)prop-2-en-1-one (TI-I-175), a synthetic chalcone... -
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- TI-I-174, a Synthetic Chalcone Derivative, Suppresses Nitric Oxide Production in Murine Macrophages via Heme Oxygenase-1 Induction and Inhibition of AP-1
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Kim MJ, Kadayat T, Kim DE, Lee ES, Park PH
- KMID: 2380315
- Biomol Ther.
- 2014 Sep;22(5):390-399.
- doi: 10.4062/biomolther.2014.062
Chalcones (1,3-diaryl-2-propen-1-ones), a flavonoid subfamily, are widely known for their anti-inflammatory properties. Propenone moiety in chalcones is known to play an important role in generating biological responses by chalcones. In... -
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- Pyrrole-Derivative of Chalcone, (E)-3-Phenyl-1-(2-Pyrrolyl)-2-Propenone, Inhibits Inflammatory Responses via Inhibition of Src, Syk, and TAK1 Kinase Activities
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Yang S, Kim Y, Jeong D, Kim JH, Kim S, Son YJ, Yoo BC, Jeong EJ, Kim TW, Han Lee IS, Cho JY
- KMID: 2374613
- Biomol Ther.
- 2016 Nov;24(6):595-603.
- doi: 10.4062/biomolther.2016.027
(E)-3-Phenyl-1-(2-pyrrolyl)-2-propenone (PPP) is a pyrrole derivative of chalcone, in which the B-ring of chalcone linked to β-carbon is replaced by pyrrole group. While pyrrole has been studied for possible Src... -
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- Phenolic Constituents from the Flowers of Hamamelis japonica Sieb. et Zucc.
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Yim SH, Lee YJ, Park KD, Lee IS, Shin BA, Jung DW, Williams D, Kim HJ
- KMID: 2312891
- Nat Prod Sci.
- 2015 Sep;21(3):162-169.
- doi: 10.0000/nps.2015.21.3.162
Hamamelis japonica (Hamamelidaceae), widely known as Japanese witch hazel, is a deciduous flowering shrub that produces compact clumps of yellow or orange-red flowers with long and thin petals. As a... -
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- Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity
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Park SH, Kwak JA, Jung SH, Ahn B, Cho WJ, Yun CY, Na CS, Hwang BY, Hong JT, Han SB, Kim Y
- KMID: 2396797
- Exp Mol Med.
- 2017 Nov;49(11):e392.
- doi: 10.1038/emm.2017.156
Mice deficient in the toll-like receptor (TLR) or the myeloid differentiation factor 88 (MyD88) are resistant to acute liver failure (ALF) with sudden death of hepatocytes. Chalcone derivatives from medicinal... -
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- A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-kappaB pathway in BV2 microglial cells
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Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K, Shin SY
- KMID: 1383799
- Exp Mol Med.
- 2012 Jun;44(6):369-377.
Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound... -
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- A Benzylideneacetophenone Derivative Induces Apoptosis of Radiation-Resistant Human Breast Cancer Cells via Oxidative Stress
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Park JE, Piao MJ, Kang KA, Shilnikova K, Hyun YJ, Oh SK, Jeong YJ, Chae S, Hyun JW
- KMID: 2386907
- Biomol Ther.
- 2017 Jul;25(4):404-410.
- doi: 10.4062/biomolther.2017.010
Benzylideneacetophenone derivative (1E)-1-(4-hydroxy-3-methoxyphenyl) hept-1-en-3-one (JC3) elicited cytotoxic effects on MDA-MB 231 human breast cancer cells-radiation resistant cells (MDA-MB 231-RR), in a dose-dependent manner, with an IC₅₀ value of 6 μM... -
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- Benzylideneacetophenone derivatives attenuate IFN-gamma-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition
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Lee SH, Lim SY, Choi JH, Jung JC, Oh S, Kook KH, Choi YH
- KMID: 2155365
- Exp Mol Med.
- 2014 Jun;46(6):e100.
- doi: 10.1038/emm.2014.26
The aim of the present study was to identify a new candidate anti-inflammatory compound for use in the active stage of thyroid-associated ophthalmopathy (TAO). Benzylideneacetophenone compound JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] was synthesized... -
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- Effects of Peroxisome Proliferator-activated Receptor-gamma Agonist on Fas-mediated Apoptosis in HT-29 Cells
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Chung YW, Han DS, Kang EK, Lee JS, Lee HR, Kim JB, Park JY, Kim YS, Lee OY, Choi HS, Sohn JH, Yoo DH, Hahm JS
- KMID: 772519
- Korean J Gastroenterol.
- 2003 Jul;42(1):35-41.
BACKGROUND/AIMS: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a critical role in adipocytes differentiation and insulin sensitivity and is also related to regulation of inflammation and cell proliferation. The aim of... -
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