- The effect of telomerase expression on the escape from M2 crisis in virus-transformed human retinal pigment epithelial cells
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Park JK, Kim BH, Han YS, Park IK
- KMID: 1081459
- Exp Mol Med.
- 2002 May;34(2):107-113.
Transformation with viral oncogene extends the lifespan of normal cells beyond replicative senescence called M1, but most of them eventually succumb to second crisis called M2 when telomeres become critically... -
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- Phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells
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Kim J, Choi BH, Jang KL, Min DS
- KMID: 1123766
- Exp Mol Med.
- 2004 Oct;36(5):454-460.
Hepatitis C Virus (HCV) is associated with a severe liver disease and increased frequency in the development of hepatocellular carcinoma. Overexpression of HCV core protein is known to transform fibroblast... -
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- Immortalization of human embryonic fibroblasts by overexpression of c-myc and simian virus 40 large T antigen
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Kim HS, Shin JY, Yun JY, Ahn DK, Lee JY
- KMID: 1457544
- Exp Mol Med.
- 2001 Dec;33(4):293-298.
SV40 large T antigen, a viral oncoprotein, is known to immortalize human diploid fibroblast by soaking up cellular RB and p53, but its frequency is extremely low. Additional genetic alteration... -
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- Downregulation of cellular prion protein inhibited the proliferation and invasion and induced apoptosis of Marek's disease virus-transformed avian T cells
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Wan X, Yang R, Liu G, Zhu M, Zhang T, Liu L, Wu R
- KMID: 2413166
- J Vet Sci.
- 2016 Jun;17(2):171-178.
- doi: 10.4142/jvs.2016.17.2.171
Cellular prion protein (PrP(C)) is ubiquitously expressed in the cytomembrane of a considerable number of eukaryotic cells. Although several studies have investigated the functions of PrP(C) in cell proliferation, cell... -
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- Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders
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Cai Q, Chen K, Young KH
- KMID: 2155398
- Exp Mol Med.
- 2015 Jan;47(1):e133.
- doi: 10.1038/emm.2014.105
Epstein-Barr virus, a ubiquitous human herpesvirus, can induce both lytic and latent infections that result in a variety of human diseases, including lymphoproliferative disorders. The oncogenic potential of Epstein-Barr virus... -
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- Dedifferentiation of conditionally immortalized hepatocytes with long-term in vitro passage
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Kim BH, Sung SR, Choi EH, Kim YI, Kim KJ, Dong SH, Kim HJ, Chang YW, Lee JI, Chang R
- KMID: 927131
- Exp Mol Med.
- 2000 Mar;32(1):29-37.
The rat hepatocytes were immortalized using a temperature-sensitive mutant of SV40 large T antigen (tsT) to develop as a possible substitute for primary hepatocytes. Four rat hepatocyte lines that have... -
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- Induction of fibronectin gene expression by inhibitors of protein phosphatase type 2B in normal and transformed fibroblasts
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Rhew JH, Shin YA, Lee BH, Park RW, Kim IS
- KMID: 1029934
- Exp Mol Med.
- 1999 Jun;31(2):71-75.
Two intracellular signal pathways mediated by cAMP and protein kinase C (PKC) were involved in the regulation of FN gene expression (Lee et al., Exp. Mol. Med. 30: 240, 1998). In this... -
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