- Effects of Magnesium sulfate on the expression of caspase-3 and caspase-9 of cytotrophoblasts under hypoxic condition
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Lee GS, Kim SJ, Hur M, Park SH, Lee HJ, Lee WS, Shin JC
- KMID: 2076856
- Korean J Obstet Gynecol.
- 2003 Mar;46(3):647-650.
OBJECTIVE: To determine the effect of magnesium sulfate (MgSO4) on the expression of caspase-3 and caspase-9 of cytotrophoblasts in vitro under normal and hypoxic condition as assessed immunoblot analyses. METHODS: Normal... -
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- Ceramide-Induced Apoptosis in Cultured Keratocyte
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Park HR, Kim TI, Tchah HW
- KMID: 2125617
- J Korean Ophthalmol Soc.
- 2003 Apr;44(4):945-954.
PURPOSE: We investigated the effect of ceramide on keratocyte apoptosis and pathway of ceramide-induced keratocyte apoptosis. METHODS: Cultured Newzealand White Rabbit keratocytes were exposed to various concentrations of ceramide type... -
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- A Study of Apoptosis in Pemphigus Vulgaris
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Roh BH, Whang KU, Cho MK, Park YL, Lee JS, Lee CW
- KMID: 2087378
- Korean J Dermatol.
- 2007 Jul;45(7):650-658.
BACKGROUND: Pemphigus vulgaris is an autoimmune bullous dermatoses of skin and mucosa characterized by loss of adhesion between keratinocytes, a process known as acantholysis. Apoptosis, programmed cell death, may participate... -
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- Activation of Caspase-3 in Hydrogen Peroxide-Induced Apoptosis of Human Leukemia HL 60 Cells
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Jeon S, Woo CW, Lee J, Sohn J, Lee KC, Son C, Lee J
- KMID: 2278318
- Korean J Pediatr Hematol Oncol.
- 2004 Oct;11(2):228-235.
PURPOSE: Reactive oxygen species have been recognized as a common signaling mediator in diverse stimuli-induced apoptosis and hydrogen peroxide is a natural one of those reactive oxygen species. This study... -
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- The Apoptosis induced by Ceramide and Phytoceramide in the Lens Epithelial Cell
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Chae JB, Kim TI, Tchah H
- KMID: 2337121
- J Korean Ophthalmol Soc.
- 2003 Nov;44(11):2627-2636.
PURPOSE: The purpose of this study was to determine if ceramide, which is known as secondary messenger of programmed cell death (apoptosis), can cause apoptosis in lens epithelial cell (LEC)... -
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- A calpain inhibitor protects against fractalkine production in lipopolysaccharide-treated endothelial cells
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Jang J, Yoon Y, Oh DJ
- KMID: 2416091
- Kidney Res Clin Pract.
- 2017 Sep;36(3):224-231.
- doi: 10.23876/j.krcp.2017.36.3.224
BACKGROUND: Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ. There... -
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- Tacrolimus (FK506) Induced Apoptotic Signal Transduction Pathway
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Jung MR, Choi SJ, Chung SY
- KMID: 2117082
- J Korean Surg Soc.
- 2007 Nov;73(5):359-365.
PURPOSE: This study examined the effects of Tacrolimus (FK506) on the expression of the apoptotic signal transduction proteins of Jurkat human T-lymphocytes. METHODS: The cell viability was examined by a... -
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- Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells
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Kang JI, Hong JY, Choi JS, Lee SK
- KMID: 2164225
- Biomol Ther.
- 2016 May;24(3):320-327.
- doi: 10.4062/biomolther.2015.145
Columbianadin (CBN), a natural coumarin from Angelica decursiva (Umbelliferae), is known to have various biological activities including anti-inflammatory and anti-cancer effects. In this study, the anti-proliferative mechanism of actions mediated... -
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- Cell Death Induction Mechanism of Non-small Cell Lung Cancer Cell Line, NCI-H1703 by Docetaxel
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Ha HC, Kim YD, Song SH, Park CS, Kim JW
- KMID: 1878599
- Korean J Thorac Cardiovasc Surg.
- 2006 Sep;39(9):668-673.
BACKGROUND: Docetaxel has been effectively used as an anti-cancer chemotherapuetic agent for various tumor treatments including lung cancer. However, the cell death induction mechanism(s) involved with docetaxel treatment in lung... -
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- MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
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Liu H, Li S, Jiang W, Li Y
- KMID: 2470910
- Korean Circ J.
- 2020 Mar;50(3):250-263.
- doi: 10.4070/kcj.2019.0107
BACKGROUND AND OBJECTIVES: To reveal the detail mechanism of miR-484 on myocardial ischemia-reperfusion (MI/R) injury. METHODS: Rats model of MI/R injury was established based on control (Con; sham operate) group, ischemia-reperfusion... -
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- Melatonin Induces Apoptotic Cell Death via p53 in LNCaP Cells
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Kim CH, Yoo YM
- KMID: 2071707
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):365-369.
- doi: 10.4196/kjpp.2010.14.6.365
In this study, we examined whether melatonin promotes apoptotic cell death via p53 in prostate LNCaP cells. Melatonin treatment significantly curtailed the growth of LNCaP cells in a dose- and... -
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- Mechanism Underlying Curcumin-induced Apoptosis and Cell Cycle Arrest on SCC25 Human Tongue Squamous Cell Carcinoma Cell Line
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Moon JB, Lee KH, Kim IR, Kim GC, Kwak HH, Park BS
- KMID: 1703488
- Int J Oral Biol.
- 2014 Mar;39(1):23-33.
Several studies have shown that curcumin, which is derived from the rhizomes of turmeric, possesses antimicrobial, antioxidant and anti-inflammatory properties. The antitumor properties of curcumin have also now been demonstrated... -
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- Bcl-2 Family and Caspases are Involved in CoCl2-Induced Apoptosis of PC12 Cells
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Jung JY, Park HJ, Kim SH, Kim WJ
- KMID: 1512981
- Korean J Phys Anthropol.
- 2006 Jun;19(2):137-148.
Hypoxic/ischemic condition induces the neuronal apoptotic events, consequently resulting in neuronal damages. Cobalt chloride (CoCl2) could mimic the hypoxic condition including the production of reactive oxygen species (ROS). This study... -
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- Anti-leukemic properties of deferasirox via apoptosis in murine leukemia cell lines
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Jeon SR, Lee JW, Jang PS, Chung NG, Cho B, Jeong DC
- KMID: 1787910
- Blood Res.
- 2015 Mar;50(1):33-39.
- doi: 10.5045/br.2015.50.1.33
BACKGROUND: Although deferasirox (DFX) is reported to have anti-tumor effects, its anti-leukemic activity remains unclear. We evaluated the effect of DFX treatment on two murine lymphoid leukemia cell lines, and... -
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- Ginsenoside Rb1 Inhibits Doxorubicin-Triggered H9C2 Cell Apoptosis via Aryl Hydrocarbon Receptor
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Zhang Y, Wang Y, Ma Z, Liang Q, Tang X, Tan H, Xiao C, Gao Y
- KMID: 2375041
- Biomol Ther.
- 2017 Mar;25(2):202-212.
- doi: 10.4062/biomolther.2016.066
Doxorubicin (DOX) is a highly effective chemotherapeutic agent; however, the dose-dependent cardiotoxicity associated with DOX significantly limits its clinical application. In the present study, we investigated whether Rb1 could prevent... -
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- The Apoptosis Induced by Ceramide in the Endothelial Cell
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Lee SY, Kim TI, Tchag H
- KMID: 2206691
- J Korean Ophthalmol Soc.
- 2003 Sep;44(9):2128-2136.
PURPOSE: To evaluate the effect of variable ceramides on the apoptosis of corneal endothelial cell and then, if ceramide induce the apoptosis in endothelial cells, via which pathway apoptosis occur.... -
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- 17-DMAG has the Potentiated Anticancer Effects Against Hepatocellular Carcinoma Cells by Transfection of the Gene Encoding Hepatitis B Viral X Protein
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Lee CS, Kim OH, Hong HE, Jeon SJ, Won SS, Kim SJ
- KMID: 2396567
- J Liver Cancer.
- 2017 Sep;17(2):126-135.
- doi: 10.17998/jlc.17.2.126
BACKGROUND/AIMS: Hepatitis B viral protein X (HBx) is implicated in the pathogenesis of hepatocellular carcinoma (HCC) as well as the elevation of heat shock proteins (HSPs) after hepatitis B virus... -
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- Effects of Recombinant EPO on Death of Cortical Neuron in Chronic Hypoxia
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Kim HJ, Baek JG, Yang JS, Kang KY, Kim KR, Kim H
- KMID: 1598729
- Korean J Phys Anthropol.
- 2005 Dec;18(4):291-301.
Chronic hypoxia has been associated with change in neurovascular behavior, mediated, in part, by erythropoietin (EPO). EPO, a hematopoietic growth factor, could act as a neurotrophic factor. In the present... -
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- Apoptosis of Keratocytes Induced by Mitomycin C
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Choi J, Kim TI, Tchah H
- KMID: 1902562
- J Korean Ophthalmol Soc.
- 2004 Mar;45(3):490-499.
PURPOSE: The purpose of this study was to evaluate the effect of mitomycin C on rabbit keratocytes for their potential to modulate corneal stromal wound healing. We also investigated the... -
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- Alteration of Apoptosis-Related Proteins (Apaf-1, Caspase-9, Bcl-2, p53, and Survivin) According to Malignant Progression in Cutaneous Melanocytic Lesions
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Kang YJ, Jung JH, Yim KI, Lee KY, Lee YS, Kang SJ, Kang CS, Kim SY
- KMID: 1443729
- Korean J Pathol.
- 2011 Jun;45(3):247-253.
- doi: 10.4132/KoreanJPathol.2011.45.3.247
BACKGROUND: Apoptosis protease activating factor-1 (Apaf-1), caspase-9, Bcl-2, p53, and survivin are important factors in the pathway of apoptosis, but their clinicopathologic significance remains unclear in human cutaneous melanoma. We... -
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