- Control of Mitochondrial Dynamics by Fas-induced Caspase-8 Activation in Hippocampal Neurons
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Cho HM, Sun W
- KMID: 2165558
- Exp Neurobiol.
- 2015 Sep;24(3):219-225.
- doi: 10.5607/en.2015.24.3.219
Cells undergo apoptosis mainly via two pathways-the mitochondrial pathway and the cytosolic pathway. It has been well documented that activation of the mitochondrial pathway promotes mitochondrial fragmentation and inhibition of... -
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- Mutational Analysis of Caspase-7 and 8 Genes in Non-small Cell Lung Cancer
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Soung YH, Lee JW, Moon SW, Jo KH, Wang YP, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH
- KMID: 1895268
- J Lung Cancer.
- 2005 Jun;4(1):38-41.
PURPOSE : Several lines of evidence have indicated that deregulation of apoptosis is involved in the mechanism of cancer development. Caspase-8 activation plays a central role in the initiation phase... -
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- Preliminary Study of Expression of Caspase mRNA and Apoptosis in Squamous Cell Carcinoma and Basal Cell Carcinoma
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Lee GY, Kim MH, Choi HY, Myung KB
- KMID: 2250258
- Korean J Dermatol.
- 2003 Jan;41(1):7-14.
BACKGROUND: Although many recent reports have suggested an important role of caspase in apoptosis and tumor, little is known about the role of caspase in cutaneous carcinoma. OBJECT: The purpose... -
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- Ceramide-Induced Apoptosis in Cultured Keratocyte
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Park HR, Kim TI, Tchah HW
- KMID: 2125617
- J Korean Ophthalmol Soc.
- 2003 Apr;44(4):945-954.
PURPOSE: We investigated the effect of ceramide on keratocyte apoptosis and pathway of ceramide-induced keratocyte apoptosis. METHODS: Cultured Newzealand White Rabbit keratocytes were exposed to various concentrations of ceramide type... -
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- A Study of Apoptosis in Pemphigus Vulgaris
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Roh BH, Whang KU, Cho MK, Park YL, Lee JS, Lee CW
- KMID: 2087378
- Korean J Dermatol.
- 2007 Jul;45(7):650-658.
BACKGROUND: Pemphigus vulgaris is an autoimmune bullous dermatoses of skin and mucosa characterized by loss of adhesion between keratinocytes, a process known as acantholysis. Apoptosis, programmed cell death, may participate... -
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- Activation of Caspase-3 in Hydrogen Peroxide-Induced Apoptosis of Human Leukemia HL 60 Cells
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Jeon S, Woo CW, Lee J, Sohn J, Lee KC, Son C, Lee J
- KMID: 2278318
- Korean J Pediatr Hematol Oncol.
- 2004 Oct;11(2):228-235.
PURPOSE: Reactive oxygen species have been recognized as a common signaling mediator in diverse stimuli-induced apoptosis and hydrogen peroxide is a natural one of those reactive oxygen species. This study... -
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- The Apoptosis induced by Ceramide and Phytoceramide in the Lens Epithelial Cell
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Chae JB, Kim TI, Tchah H
- KMID: 2337121
- J Korean Ophthalmol Soc.
- 2003 Nov;44(11):2627-2636.
PURPOSE: The purpose of this study was to determine if ceramide, which is known as secondary messenger of programmed cell death (apoptosis), can cause apoptosis in lens epithelial cell (LEC)... -
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- Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells
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Kang JI, Hong JY, Choi JS, Lee SK
- KMID: 2164225
- Biomol Ther.
- 2016 May;24(3):320-327.
- doi: 10.4062/biomolther.2015.145
Columbianadin (CBN), a natural coumarin from Angelica decursiva (Umbelliferae), is known to have various biological activities including anti-inflammatory and anti-cancer effects. In this study, the anti-proliferative mechanism of actions mediated... -
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- Apoptosis and the expression of caspase-1, 3, 8, IFN-gamma, and iNOS mRNA in Leprosy Lesions
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Choi YJ, Kim MH, Choi HY, Myung KB
- KMID: 1921045
- Korean Lepr Bull.
- 2003 Dec;36(2):3-22.
Apoptosis is an unique physiologic process of programmed cell death, playing an important role in the development and homeostasis of both normal and pathologic tissues. In mycobacterial infections, apoptosis of... -
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- Neuroprotection of lithium is associated with inhibition of Bax expression and caspase 8 activation
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Kwon GY, Kim SK
- KMID: 1607078
- Korean J Physiol Pharmacol.
- 2001 Oct;5(5):389-396.
Neuroprotective properties of lithium were investigated by using in vivo NMDA excitotoxicity model. The appearance of TUNEL positive cells was prominent within 24 h of NMDA (70 mg/kg, i.p.) injection in the regions... -
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- Melatonin Induces Apoptotic Cell Death via p53 in LNCaP Cells
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Kim CH, Yoo YM
- KMID: 2071707
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):365-369.
- doi: 10.4196/kjpp.2010.14.6.365
In this study, we examined whether melatonin promotes apoptotic cell death via p53 in prostate LNCaP cells. Melatonin treatment significantly curtailed the growth of LNCaP cells in a dose- and... -
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- Prolonged ERK Activation of S1P on B16 Melanoma Cells
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Lee HS, Choi GS, Shin JH
- KMID: 2248133
- Korean J Dermatol.
- 2008 Jun;46(6):769-775.
BACKGROUND: The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), was reported to induce apoptosis of some cancer cells and neurons, although it is generally known to exert mitogenic and antiapoptotic effects.... -
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- Bcl-2 Family and Caspases are Involved in CoCl2-Induced Apoptosis of PC12 Cells
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Jung JY, Park HJ, Kim SH, Kim WJ
- KMID: 1512981
- Korean J Phys Anthropol.
- 2006 Jun;19(2):137-148.
Hypoxic/ischemic condition induces the neuronal apoptotic events, consequently resulting in neuronal damages. Cobalt chloride (CoCl2) could mimic the hypoxic condition including the production of reactive oxygen species (ROS). This study... -
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- Anti-leukemic properties of deferasirox via apoptosis in murine leukemia cell lines
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Jeon SR, Lee JW, Jang PS, Chung NG, Cho B, Jeong DC
- KMID: 1787910
- Blood Res.
- 2015 Mar;50(1):33-39.
- doi: 10.5045/br.2015.50.1.33
BACKGROUND: Although deferasirox (DFX) is reported to have anti-tumor effects, its anti-leukemic activity remains unclear. We evaluated the effect of DFX treatment on two murine lymphoid leukemia cell lines, and... -
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- Ginsenoside Rb1 Inhibits Doxorubicin-Triggered H9C2 Cell Apoptosis via Aryl Hydrocarbon Receptor
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Zhang Y, Wang Y, Ma Z, Liang Q, Tang X, Tan H, Xiao C, Gao Y
- KMID: 2375041
- Biomol Ther.
- 2017 Mar;25(2):202-212.
- doi: 10.4062/biomolther.2016.066
Doxorubicin (DOX) is a highly effective chemotherapeutic agent; however, the dose-dependent cardiotoxicity associated with DOX significantly limits its clinical application. In the present study, we investigated whether Rb1 could prevent... -
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- The Apoptosis Induced by Ceramide in the Endothelial Cell
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Lee SY, Kim TI, Tchag H
- KMID: 2206691
- J Korean Ophthalmol Soc.
- 2003 Sep;44(9):2128-2136.
PURPOSE: To evaluate the effect of variable ceramides on the apoptosis of corneal endothelial cell and then, if ceramide induce the apoptosis in endothelial cells, via which pathway apoptosis occur.... -
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- 17-DMAG has the Potentiated Anticancer Effects Against Hepatocellular Carcinoma Cells by Transfection of the Gene Encoding Hepatitis B Viral X Protein
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Lee CS, Kim OH, Hong HE, Jeon SJ, Won SS, Kim SJ
- KMID: 2396567
- J Liver Cancer.
- 2017 Sep;17(2):126-135.
- doi: 10.17998/jlc.17.2.126
BACKGROUND/AIMS: Hepatitis B viral protein X (HBx) is implicated in the pathogenesis of hepatocellular carcinoma (HCC) as well as the elevation of heat shock proteins (HSPs) after hepatitis B virus... -
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- Effects of Recombinant EPO on Death of Cortical Neuron in Chronic Hypoxia
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Kim HJ, Baek JG, Yang JS, Kang KY, Kim KR, Kim H
- KMID: 1598729
- Korean J Phys Anthropol.
- 2005 Dec;18(4):291-301.
Chronic hypoxia has been associated with change in neurovascular behavior, mediated, in part, by erythropoietin (EPO). EPO, a hematopoietic growth factor, could act as a neurotrophic factor. In the present... -
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- Apoptosis of Keratocytes Induced by Mitomycin C
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Choi J, Kim TI, Tchah H
- KMID: 1902562
- J Korean Ophthalmol Soc.
- 2004 Mar;45(3):490-499.
PURPOSE: The purpose of this study was to evaluate the effect of mitomycin C on rabbit keratocytes for their potential to modulate corneal stromal wound healing. We also investigated the... -
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- TRAIL-induced cell death and caspase-8 activation are inhibited by cisplatin but not carboplatin
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Han SJ, Ahn TK, Choi HS, Shin JN, Piya S, Kim TH
- KMID: 2245094
- J Gynecol Oncol.
- 2009 Jun;20(2):113-116.
- doi: 10.3802/jgo.2009.20.2.113
OBJECTIVE: Platinum (Pt) based drugs including cisplatin and carboplatin are widely used as anticancer drugs in various human cancers. Many studies have shown that chemotherapeutic agents synergistically enhance cell death... -
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