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Prediction of Cancer Incidence and Mortality in Korea, 2023

Jung KW, Kang MJ, Park EH, Yun EH, Kim HJ, Kong HJ, Im JS, Seo HG

Purpose This study aimed to report the projected cancer incidence and mortality for the year 2023 to estimate Korea’s current cancer burden. Materials and Methods Cancer incidence data from 1999 to...
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Hepatitis B Virus Reactivation in a Chronic Lymphocytic Leukemia Patient Treated with Ibrutinib

Choi JH, Hur JY, Won YW

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Trends and Patterns of Cancer Burdens by Region and Income Level in Korea: A National Representative Big Data Analysis

Jung YS, Yoon SJ

Purpose This study aimed to elucidate the trends and characteristics of the cancer burden in Korea by cancer site, region, and income level. Materials and Methods Korean National Burden of Disease research...
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Utilizing Plasma Circulating Tumor DNA Sequencing for Precision Medicine in the Management of Solid Cancers

Cha Y, Kim S, Han SW

Plasma circulating tumor DNA (ctDNA) sequencing has demonstrated clinical utility for tumor molecular profiling at initial diagnosis or tumor progression in advanced solid cancers and is being rapidly incorporated into...
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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2020

Kang MJ, Jung KW, Bang SH, Choi SH, Park EH, Yun EH, Kim HJ, Kong HJ, Im JS, Seo HG, The Community of Population-Based Regional Cancer Registries*

Purpose The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2020. Materials and Methods Incidence, survival, and prevalence rates of...
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Clinical Circulating Tumor DNA Testing for Precision Oncology

Kim H, Park KU

Circulating tumor DNA (ctDNA) is the portion of the cell-free DNA in the blood of cancer patients released from tumor cells via apoptosis, necrosis, or active release. From 10 mL...
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Androgen Receptor as a Predictive Marker for Pathologic Complete Response in Hormone Receptor–Positive and HER-2–Negative Breast Cancer with Neoadjuvant Chemotherapy

Lee EG, Lee DE, Kim Hh, Han JH, Lee S, Kang HS, Lee ES, Chae H, Sim SH, Lee KS, Kwon Y, Jung SY

Purpose This study investigated pathological complete response (pCR) according to androgen receptor (AR) in breast cancer patients undergoing neoadjuvant chemotherapy and estimated the relationship between AR expression and clinicopathological factors. Materials...
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A Nationwide Study of Differences in Surgical Treatment Rates and Oncological Outcomes for Prostate Cancer according to Economic Status and Region

Yoo S, Oh S, Cho MC, Son H, Jeong H

Purpose We investigated the effects of economic status (classified based on insurance type and residential area) on oncological outcomes of prostate cancer using a nationwide database. We additionally investigated oncological...
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Marked Reduction in the Risk of Dementia in Patients with Breast Cancer: A Nationwide Population-Based Cohort Study

Oh J, Lee HS, Jeon S, Seok JH, Yoo TK, Park WC, Yoon CI

Purpose An inverse relationship between cancer and neurodegenerative disease, which presents the possibility of a reduced risk of dementia in cancer patients, has been suggested previously. However, a nationwide longitudinal...
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Retrospective Cohort Study on the Long-term Oncologic Outcomes of Sentinel Lymph Node Mapping Methods (Dye-Only versus Dye and Radioisotope Mapping) in Early Breast Cancer: A Propensity Score-Matched Analysis

Lim C, Kang E, Jung JG, Cheun JH, Kim HK, Lee HB, Moon HG, Han W

Purpose In sentinel lymph node (SLN) biopsy (SLNB) during breast cancer surgery, SLN mapping using dye and isotope (DUAL) may have lower false-negative rates than the dye-only (DYE) method. However,...
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Effectiveness of Self-Assessment, TAilored Information, and Lifestyle Management for Cancer Patients’ Returning to Work (START): A Multi-center, Randomized Controlled Trial

Kang D, Bae KR, Ahn Y, Kim N, Nam SJ, Lee JE, Lee SK, Shim YM, Sinn DH, Oh SY, Chun M, Heo J, Cho J

Purpose We developed a comprehensive return to work (RTW) intervention covering physical, psycho-social and practical issues for patients newly diagnosed and evaluated its efficacy in terms of RTW. Materials and Methods...
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Real World Characteristics and Clinical Outcomes of HER2-Mutant Non–Small Cell Lung Cancer Patients Detected by Next-Generation Sequencing

Ahn BC, Han YJ, Kim HR, Hong MH, Cho BC, Lim SM

Purpose This study was conducted to investigate the clinical characteristics of patients with advanced non–small cell lung cancer (NSCLC) harboring human epidermal growth factor receptor 2 (HER2) mutations and to...
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PIK3CA Mutation is Associated with Poor Response to HER2-Targeted Therapy in Breast Cancer Patients

Kim JW, Lim AR, You JY, Lee JH, Song SE, Lee NK, Jung SP, Cho KR, Kim CY, Park KH

Purpose Mutations in the PIK3CA gene occur frequently in breast cancer patients. Activating PIK3CA mutations confer resistance to human epidermal growth factor receptor 2 (HER2)-targeted treatments. In this study, we investigated...
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Quality Assessment and Trend for Breast Cancer Treatment Practice across South Korea Based on Nationwide Analysis of Korean Health Insurance Data during 2013-2017

Choi KH, Sung SY, Lee SW, Jeon YW, Kim SH, Lee JH

Purpose Quality assessment of breast cancer treatment in South Korea showed the upward standardization of the grade since 2013, but treatment disparities still have existed. This study analyzed the five...
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Optimal Definition of Oligometastasis Showing Survival Benefits of Local Therapies during Tyrosine Kinase Inhibitor Treatment

Jang YJ, Hyun Dg, Ji W, Choi CM, Yoon S, Lee DH, Kim SW, Lee JC

Purpose We aimed to investigate the feasibility of four criteria on oligometastasis (OM) concerning clear survival benefits of local therapy (LT) during tyrosine kinase inhibitor (TKI) treatment in non–small cell...
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Cancer-Specific Sequences in the Diagnosis and Treatment of NUT Carcinoma

Lee MS, An S, Song JY, Sung M, Jung K, Chang ES, Choi J, Oh DY, Jeon YK, Yang H, Lakshmi C, Park S, Han J, Lee SH, Choi YL

Purpose NUT carcinoma (NC) is a solid tumor caused by the rearrangement of NUTM1 that usually develops in midline structures, such as the thorax. No standard treatment has been established...
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Descriptive Analysis of Gastric Cancer Mortality in Korea, 2000-2020

Hoang T, Woo H, Cho S, Lee J, Kazmi SZ, Shin A

Purpose This study aimed to examine secular trends, age-period-cohort effects, and geographical differences in gastric cancer (GC) mortality in Korea. Materials and Methods Using cause of death data from the Korean Statistical Information...
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Trastuzumab Combined with Irinotecan in Patients with HER2-Positive Metastatic Colorectal Cancer: A Phase II Single-Arm Study and Exploratory Biomarker Analysis

Xu T, Wang X, Xin Y, Wang Z, Gong J, Zhang X, Li Y, Ji C, Sun Y, Zhao F, Huang D, Bai Y, Li J, Shen L

Purpose The human epidermal growth factor receptor 2 (HER2) is an established therapeutic target for various kinds of solid tumors. HER2 amplification occurs in approximately 1% to 6% of colorectal...
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Impact of Postmastectomy Radiation Therapy on Breast Cancer Patients According to Pathologic Nodal Status after Modern Neoadjuvant Chemotherapy

Kim D, Kim JH, Kim IA, Chang JH, Shin KH

Purpose The utility of postmastectomy radiation therapy (PMRT) for breast cancer patients after neoadjuvant chemotherapy (NAC) is highly controversial. This study evaluated the impact of PMRT according to pathologic nodal...
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Colonoscopic Screening and Risk of All-Cause and Colorectal Cancer Mortality in Young and Older Individuals

Lee JA, Chang Y, Kim Y, Park DI, Park SK, Park HY, Koh J, Lee SJ, Ryu S

Purpose The incidence of early-onset colorectal cancer (CRC) and associated mortality have been increasing. However, the potential benefits of CRC screening are largely unknown in young individuals. We aimed to...
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