- Structural Insights for β-Lactam Antibiotics
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Kim D, Kim S, Kwon Y, Kim Y, Park H, Kwak K, Lee H, Lee JH, Jang KM, Kim D, Lee SH, Kang LW
- KMID: 2539582
- Biomol Ther.
- 2023 Mar;31(2):141-147.
- doi: 10.4062/biomolther.2023.008
Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds... -
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- Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Na v 1.7 and Na v 1.5
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Bok CS, Kim RE, Cho YY, Choi JS
- KMID: 2539585
- Biomol Ther.
- 2023 Mar;31(2):168-175.
- doi: 10.4062/biomolther.2023.002
Tramadol is an opioid analog used to treat chronic and acute pain. Intradermal injections of tramadol at hundreds of millimoles have been shown to produce a local anesthetic effect. We... -
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- NJK14047 Suppression of the p38 MAPK Ameliorates OVA-Induced Allergic Asthma during Sensitization and Challenge Periods
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Lee JH, Son SH, Kim NJ, Im DS
- KMID: 2539587
- Biomol Ther.
- 2023 Mar;31(2):183-192.
- doi: 10.4062/biomolther.2022.078
p38 MAPK has been implicated in the pathogenesis of asthma as well as pro-allergic Th2 cytokines, orosomucoid-like protein isoform 3 (ORMDL3), regulation of sphingolipid biosynthesis, and regulatory T cell-derived IL-35.... -
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- The Effect of Luteolin on the Modulation of Vascular Contractility via ROCK and CPI-17 Inactivation
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Yoon HJ, Kang DH, Jin F, Bang JS, Sohn UD, Je HD
- KMID: 2539588
- Biomol Ther.
- 2023 Mar;31(2):193-199.
- doi: 10.4062/biomolther.2022.087
In this investigation, we made a study of the efficacy of luteolin (a flavonoid found in plants such as vegetables, herbs and fruits) on vascular contractibility and to elucidate the... -
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- Megakaryocyte-Derived IL-8 Acts as a Paracrine Factor for Prostate Cancer Aggressiveness through CXCR2 Activation and Antagonistic AR Downregulation
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Dahal S, Chaudhary P, Jung YS, Kim JA
- KMID: 2539590
- Biomol Ther.
- 2023 Mar;31(2):210-218.
- doi: 10.4062/biomolther.2023.005
Prostate cancer is the fifth leading cause of cancer-related mortality in men, primarily because of treatment resistance, recurrence, and metastasis. In the present study, we investigated the role of paracrine... -
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- 8-Methoxypsoralen Induces Apoptosis by Upregulating p53 and Inhibits Metastasis by Downregulating MMP-2 and MMP-9 in Human Gastric Cancer Cells
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Choi EK, Kim HD, Park EJ, Song SY, Phan TT, Nam M, Kim M, Kim DU, Hoe KL
- KMID: 2539591
- Biomol Ther.
- 2023 Mar;31(2):219-226.
- doi: 10.4062/biomolther.2023.004
Furanocoumarin 8-methoxypsoralen (8-MOP) is the parent compound that naturally occurs in traditional medicinal plants used historically. 8-MOP has been employed as a photochemotherapeutic component of Psoralen + Ultraviolet A (PUVA)... -
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- Phytochemicals That Act on Synaptic Plasticity as Potential Prophylaxis against Stress-Induced Depressive Disorder
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Yoon S, Iqbal H, Kim SM, Jin M
- KMID: 2539583
- Biomol Ther.
- 2023 Mar;31(2):148-160.
- doi: 10.4062/biomolther.2022.116
Depression is a neuropsychiatric disorder associated with persistent stress and disruption of neuronal function. Persistent stress causes neuronal atrophy, including loss of synapses and reduced size of the hippocampus and... -
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- Structure–Activity Relationship and Evaluation of Phenethylamine and Tryptamine Derivatives for Affinity towards 5-Hydroxytryptamine Type 2A Receptor
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Wang S, Zhu A, Paudel S, Jang CG, Lee YS, Kim KM
- KMID: 2539586
- Biomol Ther.
- 2023 Mar;31(2):176-182.
- doi: 10.4062/biomolther.2022.096
Among 14 subtypes of serotonin receptors (5-HTRs), 5-HT 2AR plays important roles in drug addiction and various psychiatric disorders. Agonists for 5-HT 2AR have been classified into three structural groups:... -
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- Hycanthone Inhibits Inflammasome Activation and Neuroinflammation-Induced Depression-Like Behaviors in Mice
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Boo KJ, Gonzales EL, Remonde CG, Seong JY, Jeon SJ, Park YM, Ham BJ, Shin CY
- KMID: 2539584
- Biomol Ther.
- 2023 Mar;31(2):161-167.
- doi: 10.4062/biomolther.2022.073
Despite the various medications used in clinics, the efforts to develop more effective treatments for depression continue to increase in the past decades mainly because of the treatment-resistant population, and... -
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- 4-F-PCP, a Novel PCP Analog Ameliorates the Depressive-Like Behavior of Chronic Social Defeat Stress Mice via NMDA Receptor Antagonism
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Ortiz DMD, Kim M, Lee HJ, Botanas CJ, Perez Custodio RJ, Sayson LV, Campomayor NB, Lee C, Lee YS, Cheong JH, Kim HJ
- KMID: 2539592
- Biomol Ther.
- 2023 Mar;31(2):227-239.
- doi: 10.4062/biomolther.2022.159
Major depressive disorder is a leading cause of disability in more than 280 million people worldwide. Monoamine-based antidepressants are currently used to treat depression, but delays in treatment effects and... -
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- Picropodophyllotoxin Inhibits Cell Growth and Induces Apoptosis in Gefitinib-Resistant Non-Small Lung Cancer Cells by Dual-Targeting EGFR and MET
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Lee JY, Kang BY, Jung SJ, Kwak AW, Lee SO, Park JW, Joo SH, Yoon G, Lee MH, Shim JH
- KMID: 2539589
- Biomol Ther.
- 2023 Mar;31(2):200-209.
- doi: 10.4062/biomolther.2022.113
Patients with non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) amplification or sensitive muta-tions initially respond to the tyrosine kinase inhibitor gefitinib, however, the treatment becomes less effective... -
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