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An Association between 609 C --> T Polymorphism in NAD(P)H: Quinone Oxidoreductase 1 (NQO1) Gene and Blood Glucose Levels in Korean Population

Kim D

BACKGROUND: NAD(P)H: quinone oxidoreductase 1 (NQO1), which is an obligate two-electron reductase that utilizes NAD(P)H as an electron donor and is involved in the protection against oxidative stress, is likely...
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Study on Optimization of Detection System of Prompt Gamma Distribution for Proton Dose Verification

Lee HR, Min CH, Park JH, Kim SH, Kim CH

  • KMID: 1436505
  • Prog Med Phys.
  • 2012 Sep;23(3):162-168.
In proton therapy, in vivo dose verification is one of the most important parts to fully utilize characteristics of proton dose distribution concentrating high dose with steep gradient and guarantee...
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Inactivation of Aconitase by Tetrahydrobiopterin in DArgic Cells: Relevance to PD

Yoon NS, Cho Y, Lee SY, Choi HJ, Hwang O

Oxidative damage is thought to be a major cause of the progression of dopamine (DA)rgic neurodegeneration as in Parkinson's disease. We have previously reported that tetrahydrobiopterin (BH4), an endogenous molecule...
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Antidote for acetaminophen poisoning: N-acetylcysteine

Chun BJ, Moon JM, Kim SH

N-acetylcysteine (NAC) is widely recognized as the antidote of choice for acetaminophen overdose. Acetaminophen is a commonly used analgesic and antipyretic agent, and its use is one of the most...
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Antioxidant effects of fucoxanthin rich powder in rats fed with high fat diet

Ha AW, Na SJ, Kim WK

  • KMID: 2313697
  • Nutr Res Pract.
  • 2013 Dec;7(6):475-480.
The purpose of this study was to determine the antioxidant effect of fucoxanthin. After rats were fed a normal fat diet (NF), high fat diet (HF), and high fat with...
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Scolicidal Effects of Black Cumin Seed (Nigella sativa) Essential Oil on Hydatid Cysts

Mahmoudvand H, Dezaki ES, Kheirandish F, Ezatpour B, Jahanbakhsh S, Harandi MF

Surgery remains the preferred treatment for hydatid cyst (cystic echinococcosis, CE). Various scolicidal agents have been used for inactivation of protoscolices during surgery, but most of them are associated with...
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Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitro

Zhang XH, Wu H, Tang S, Li QN, Xu J, Zhang M, Su YN, Yin B, Zhao QL, Kemper N, Hartung J, Bao ED

To determine heat-shock protein (Hsp)90 expression is connected with cellular apoptotic response to heat stress and its mechanism, chicken (Gallus gallus) primary myocardial cells were treated with the Hsp90 promoter,...
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The Effect of Tanespimycin (17-AAG) on Radioiodine Accumulation in Sodium-Iodide Symporter Expressing Cells

Yu KH, Youn H, Song MG, Lee DS, Chung JK

  • KMID: 1427732
  • Nucl Med Mol Imaging.
  • 2012 Dec;46(4):239-246.
PURPOSE: The heat shock protein 90 inhibitor, tanespimycin, is an anticancer agent known to increase iodine accumulation in normal and cancerous thyroid cells. Iodine accumulation is regulated by membrane proteins...
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Enhancement of radiation effect using beta-lapachone and underlying mechanism

Ahn KJ, Lee HS, Bai SK, Song CW

Beta-lapachone (beta-Lap; 3,4-dihydro-2, 2-dimethyl-2H-naphthol[1, 2-b]pyran-5,6-dione) is a novel anti-cancer drug under phase I/II clinical trials. beta-Lap has been demonstrated to cause apoptotic and necrotic death in a variety of human...
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Effect of Pertussis Toxin and Herbimycin A on Proteinase-Activated Receptor 2-Mediated Cyclooxygenase 2 Expression in Helicobacter pylori-Infected Gastric Epithelial AGS Cells

Seo JH, Seo JY, Chung HY, Kim H

Helicobacter pylori (H. pylori) is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Proteinase-activated receptor 2 (PAR2), subgroup of G-protein coupled receptor family, is highly expressed...
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