- The Role of Beta Blockers in Treating Hypertensive Patients
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Lim SY
- KMID: 2172264
- Chonnam Med J.
- 2009 Aug;45(2):75-78.
- doi: 10.4068/cmj.2009.45.2.75
Beta-blockers have been used to treat hypertension for many years. Although beta-blockers can lower blood pressure, current data concerning the efficacy of these drugs have been disappointing, and the value... -
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- Protective Effect of Decursinol on Mouse Models of Sepsis: Enhancement of Interleukin-10
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Jung JS, Yan JJ, Song DK
- KMID: 1486147
- Korean J Physiol Pharmacol.
- 2008 Apr;12(2):79-81.
- doi: 10.4196/kjpp.2008.12.2.79
The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models... -
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- Update on Newer Antihypertensive Medicines
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Park CG
- KMID: 2188348
- J Korean Med Assoc.
- 2010 Aug;53(8):717-722.
- doi: 10.5124/jkma.2010.53.8.717
The majority of hypertensive patients do not achieve target blood pressure for a variety of reasons, including insufficient medication, drug resistance, and noncompliance. There remains a significant need to develop... -
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- Actions of potassium channel openers in rat detrusor urinae
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Kim SJ, Kim NS, Lee JL
- KMID: 1421952
- J Korean Med Sci.
- 1993 Feb;8(1):53-59.
- doi: 10.3346/jkms.1993.8.1.53
This study was performed to investigate the action of potassium channel openers on the mechanical activity of detrusor muscle isolated from rats. Detrusor muscle strips, 15 mm in length, were... -
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- Comparison of the Effects of Prophylactic Nonsteroidal Anti-inflammatory Drugs on Macular Edema After Cataract Surgery
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Chun BY, Kang SY, Song JS, Kim HM
- KMID: 2213758
- J Korean Ophthalmol Soc.
- 2010 Jul;51(7):935-940.
- doi: 10.3341/jkos.2010.51.7.935
PURPOSE: To evaluate and compare the efficacy of prophylactic administration of topical nonsteroidal anti-inflammatory (NSAID) drugs on macular edema (ME) following cataract surgery. METHODS: The present open-label non-masked randomized (random number... -
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- Antioxidant activities of licorice-derived prenylflavonoids
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Kim HJ, Seo JY, Suh HJ, Lim SS, Kim JS
- KMID: 2313633
- Nutr Res Pract.
- 2012 Dec;6(6):491-498.
Glycyrrhiza uralensis (or licorice) is a widely used Oriental herbal medicine from which the phenylflavonoids dehydroglyasperin C (DGC), dehydroglyasperin D (DGD), and isoangustone A (IsoA) are derived. The purpose of... -
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- Effect of Decursin on the Expression of beta-Catenin and Matrix Metalloproteinase-7 in Prostate Cancer Cell Lines
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Choi IJ, Min K, Oh S, Song GY, Kang D
- KMID: 2140119
- Korean J Urol.
- 2009 Jan;50(1):81-88.
- doi: 10.4111/kju.2009.50.1.81
PURPOSE: Alterations in the Wnt/beta-catenin pathway are associated with the development and progression of human prostate cancer. Decursin can attenuate the Wnt/beta-catenin pathway. We investigated the relationship between the Wnt/beta-catenin... -
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- Migration of Vascular Smooth Muscle Cells by High Glucose is Reactive Oxygen Dependent
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An YS, Kwon JH, Kang YH, Kim IJ, Kim YK, Son SM
- KMID: 2298089
- Korean Diabetes J.
- 2008 Jun;32(3):185-195.
- doi: 10.4093/kdj.2008.32.3.185
BACKGROUND: Oxidative stress contributes to vascular diseases in patients with diabetes. As the mechanism of development and progression of diabetic vascular complications is poorly understood, this study was aimed to... -
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- Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCdelta and p38 in Human Airway Epithelial Cells
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Bae CH, Kim HS, Song SY, Kim YD
- KMID: 2134600
- Clin Exp Otorhinolaryngol.
- 2012 Sep;5(3):161-169.
- doi: 10.3342/ceo.2012.5.3.161
OBJECTIVES: Phorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins. MUC16, one of the membrane-bound mucins, is... -
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- Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cdelta and epsilon
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Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS
- KMID: 1432763
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):51-56.
- doi: 10.4196/kjpp.2013.17.1.51
Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by... -
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- The Toxicity of Nonsteroidal Anti-inflammatory Eye Drops against Human Corneal Epithelial Cells in Vitro
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Lee JS, Kim YH, Park YM
- KMID: 2359972
- J Korean Med Sci.
- 2015 Dec;30(12):1856-1864.
- doi: 10.3346/jkms.2015.30.12.1856
This study investigated the toxicity of commercial non-steroid anti-inflammatory drug (NSAID) eye solutions against corneal epithelial cells in vitro. The biologic effects of 1/100-, 1/50-, and 1/10-diluted bromfenac sodium, pranoprofen,... -
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- KR-31831, a new synthetic anti-ischemic agent, inhibits in vivo and in vitro angiogenesis
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Yi EY, Park SY, Song HS, Son MJ, Yi KY, Yoo SE, Kim YJ
- KMID: 1098084
- Exp Mol Med.
- 2006 Oct;38(5):502-508.
Angiogenesis is considered to be an integral process to the growth and spread of solid tumors. Anti-angiogenesis therapy recently has been found to be one of the most promising anti-cancer... -
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- Rottlerin enhances IL-1beta-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells
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Park EJ, Kwon TK
- KMID: 1058704
- Exp Mol Med.
- 2011 Dec;43(12):669-675.
- doi: 10.3858/emm.2011.43.12.077
Cyclooxygenase-2 (COX-2) is an important enzyme in inflammation. In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231... -
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- Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways
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Kim SJ, Jeong CW, Bae HB, Kwak SH, Son JK, Seo CS, Lee HJ, Lee J, Yoo KY
- KMID: 1372805
- J Korean Med Sci.
- 2012 May;27(5):572-575.
- doi: 10.3346/jkms.2012.27.5.572
Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of... -
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- The effects of cromakalim on the mediator releases from guinea pig lung mast cell activated by specific antigen-antibody reactions
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Ro JY, Yim YN, Kim KH
- KMID: 699910
- Yonsei Med J.
- 1996 Oct;37(5):325-338.
- doi: 10.3349/ymj.1996.37.5.325
The inhibitory effect of cromakalim on the mediator release from mast cells caused by antigenantibody reactions was in controversy with the specific antigen used. However, it has recently been observed... -
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- Evaluation of Antiangiogenic Effects of a New Synthetic Candidate Drug KR-31831 on Xenografted Ovarian Carcinoma Using Dynamic Contrast Enhanced MRI
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Yang J, Kim JH, Im GH, Heo H, Yoon S, Lee J, Lee JH, Jeon P
- KMID: 1116446
- Korean J Radiol.
- 2011 Oct;12(5):602-610.
- doi: 10.3348/kjr.2011.12.5.602
OBJECTIVE: The purpose of this research was to investigate the anti-angiogenic inhibitory effect of KR-31831, a newly developed anti-angiogenic agent, on an in vivo human ovarian carcinoma model using dynamic... -
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- Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase
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Byun HS, Won M, Park KA, Kim YR, Choi BL, Lee H, Hong JH, Piao L, Park J, Kim JM, Kweon GR, Kang SH, Han J, Hur GM
- KMID: 1052941
- Exp Mol Med.
- 2008 Apr;40(2):186-195.
- doi: 10.3858/emm.2008.40.2.186
Previous studies have demonstrated that rottlerin, a specific PKCdelta inhibitor, potentiates death receptor- mediated apoptosis through a cytochrome c-dependent or -independent pathway. However, its ability to regulate necrotic cell death,... -
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- KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model
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Choi JH, Yoo JY, Kim SO, Yoo SE, Oh GT
- KMID: 1402317
- Exp Mol Med.
- 2012 Dec;44(12):733-739.
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemia-reperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive... -
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