- ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus
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Lee YS, Kang JW, Lee YH, Kim DW
- KMID: 1447422
- Anat Cell Biol.
- 2011 Jun;44(2):128-134.
- doi: 10.5115/acb.2011.44.2.128
Inhibitor of DNA binding (ID) proteins bind to and inhibit the function of basic helix-loop-helix transcription factors, including those that regulate proliferation and differentiation during development. However, little is known... -
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- Regulatory Role of Hypoxia Inducible Factor in the Biological Behavior of Nucleus Pulposus Cells
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Li H, Liang CZ, Chen QX
- KMID: 2158211
- Yonsei Med J.
- 2013 Jul;54(4):807-812.
- doi: 10.3349/ymj.2013.54.4.807
Intervertebral disc (IVD) degeneration is implicated as a major cause of low back pain. The alternated phenotypes, reduced cell survival, decreased metabolic activity, loss of matrix production and dystrophic mineralization... -
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- Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy
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Yu T, Tang B, Sun X
- KMID: 2419104
- Yonsei Med J.
- 2017 May;58(3):489-496.
- doi: 10.3349/ymj.2017.58.3.489
Hypoxia is frequently observed in solid tumors and also one of the major obstacles for effective cancer therapies. Cancer cells take advantage of their ability to adapt hypoxia to initiate... -
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- Identification of abnormal gene expression in bovine transgenic somatic cell nuclear transfer embryos
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Cho J, Kang S, Lee BC
- KMID: 1784643
- J Vet Sci.
- 2014 Jun;15(2):225-231.
- doi: 10.4142/jvs.2014.15.2.225
This study was conducted to investigate the expression of three genes related to early embryonic development in bovine transgenic cloned embryos. To accomplish this, development of bovine transgenic somatic cell... -
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- The Relationship between HIF-2α and VEGF with Radiographic Severity in the Primary Osteoarthritic Knee
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Jian-lin Z, Hong-song , Hao P, Shuang D, Shen C, Jian-ping , Bo Q, Jin-qing W, Feng L
- KMID: 2374095
- Yonsei Med J.
- 2016 May;57(3):735-740.
- doi: 10.3349/ymj.2016.57.3.735
PURPOSE: The aim of this study was to determine the relationship of hypoxia-inducible factor-2 (HIF-2α) and vascular endothelial growth factor (VEGF) with radiographic severity in primary osteoarthritis (OA) of the... -
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- Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm
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Yoon H, Kim N, Shin CM, Lee HS, Kim BK, Kang GH, Kim JM, Kim JS, Lee DH, Jung HC
- KMID: 2363967
- Gut Liver.
- 2016 Mar;10(2):228-236.
- doi: 10.5009/gnl14472
BACKGROUND/AIMS: To identify the risk factors for metachronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. METHODS: We prospectively collected clinicopathologic data and measured the methylation... -
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- Crosstalk between FLS and chondrocytes is regulated by HIF-2alpha-mediated cytokines in arthritis
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Huh YH, Lee G, Song WH, Koh JT, Ryu JH
- KMID: 2359884
- Exp Mol Med.
- 2015 Dec;47(12):e197.
- doi: 10.1038/emm.2015.88
Rheumatoid arthritis (RA) and osteoarthritis (OA), two common types of arthritis, affect the joints mainly by targeting the synovium and cartilage. Increasing evidence indicates that a significant network connects synovitis... -
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- A Novel Translocation t(1;5)(p32;q31) that Was Not Associated with the TAL1 Rearrangement in a Case of T Lymphoblastic Leukemia/Lymphoma
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Cho HS, Kim MK, Bae YK
- KMID: 1096970
- Korean J Lab Med.
- 2009 Jun;29(3):199-203.
- doi: 10.3343/kjlm.2009.29.3.199
Chromosome 1 band p32 (1p32) aberrations are common in T lymphoblastic leukemia/lymphoma (T-ALL/LBL). Two types of 1p32 aberrations include translocations with different partners and submicroscopic interstitial deletion. Both aberrations are... -
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- Regulation of glucose metabolism-related genes and VEGF by HIF-1alpha and HIF-1beta, but not HIF-2alpha, in gastric cancer
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Song IS, Wang AG, Yoon SY, Kim JM, Kim JH, Lee DS, Kim NS
- KMID: 756286
- Exp Mol Med.
- 2009 Jan;41(1):51-58.
- doi: 10.3858/emm.2009.41.1.007
Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of target genes involved in crucial aspects of cancer development. This study investigated the expression of HIFs and their contribution... -
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- Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6
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Lee YJ, Han DH, Pak YK, Cho S
- KMID: 1401756
- Exp Mol Med.
- 2012 Nov;44(11):642-652.
Low density lipoprotein receptor (LDLR) plays an important role in the cholesterol homeostasis. We examined the possible circadian regulation of LDLR and mechanism(s) underlying it. In mice, blood glucose and... -
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- Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic beta cells
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Ma WN, Park SY, Han JS
- KMID: 1078361
- Exp Mol Med.
- 2010 Jun;42(6):456-464.
- doi: 10.3858/emm.2010.42.6.047
As glucose is known to induce insulin secretion in pancreatic beta cells, this study investigated the role of a phospholipase D (PLD)-related signaling pathway in insulin secretion caused by high... -
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- Identification of a Novel Deletion Region in 3q29 Microdeletion Syndrome by Oligonucleotide Array Comparative Genomic Hybridization
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Seo EJ, Jun KR, Yoo HW, Yoo HK, Lee JO
- KMID: 1096822
- Korean J Lab Med.
- 2010 Feb;30(1):70-75.
- doi: 10.3343/kjlm.2010.30.1.70
BACKGROUND: The 3q29 microdeletion syndrome is a genomic disorder characterized by mental retardation, developmental delay, microcephaly, and slight facial dysmorphism. In most cases, the microdeletion spans a 1.6-Mb region between... -
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