- Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
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Kanaoka Y, Boyce JA
- KMID: 2260208
- Allergy Asthma Immunol Res.
- 2014 Jul;6(4):288-295.
- doi: 10.4168/aair.2014.6.4.288
Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties... -
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- Study on the action by PAF on IL-1 modulation in alveolar macrophages: Involvement of endogenous arachidonate metabolites and intracellular Ca++ mobilization
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Lee J, Kim WK, Hah JS
- KMID: 1562327
- Korean J Physiol Pharmacol.
- 1998 Apr;2(2):241-249.
Platelet-activating factor (PAF) enhanced interleukin-1 (IL-1) activity by the interaction with a specific receptor in rat alveolar macrophages. In this study, we investigated the role of endogenous arachidonate metabolites and intracellular calcium mobilization... -
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- The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells
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Lim JC, Park SY, Nam Y, Nguyen TT, Sohn UD
- KMID: 1493963
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):313-320.
- doi: 10.4196/kjpp.2012.16.5.313
In this study, we focused to identify whether eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone), an extract from Artemisia argyi folium, prevents H2O2-induced injury of cultured feline esophageal epithelial cells. Cell viability was measured by... -
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- 5-Lipoxygenase Promotor Polymorphism in Nasal Polyp Patients
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Park SK, Choi JB, Jung H, Yea SS
- KMID: 2276733
- Korean J Otolaryngol-Head Neck Surg.
- 2007 Apr;50(4):310-313.
BACKGROUND AND OBJECTIVES: Nasal polyps are the most common mass lesions in the nasal cavity and occur on both infectious and noninfectious basis, and genetic etiology is suspected in the... -
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- Enhanced Effect of Combinatorial Inhibition of Cyclooxygenase-2 and 5-Lipoxygenase on Head and Neck Cancer Cells
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Park SW, Sung MW
- KMID: 2037230
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2010 Jul;53(7):430-435.
- doi: 10.3342/kjorl-hns.2010.53.7.430
BACKGROUND AND OBJECTIVES: It has recently been found that arachidonate 5-lipoxygenase (5-lipoxygenase, 5-LO or ALOX5), another molecule capable of arachidonic acid (AA) metabolism, might promote cancer cell viability through unique... -
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- LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-kappaB Pathways
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Lee SJ, Seo KW, Kim CD
- KMID: 1791428
- Korean J Physiol Pharmacol.
- 2015 May;19(3):263-268.
- doi: 10.4196/kjpp.2015.19.3.263
5-Lipoxygenase (5-LO) plays a pivotal role in the progression of atherosclerosis. Therefore, this study investigated the molecular mechanisms involved in 5-LO expression on monocytes induced by LPS. Stimulation of THP-1... -
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- Rhamnazin inhibits LPS-induced inflammation and ROS/RNS in raw macrophages
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Kim YJ
- KMID: 2357131
- J Nutr Health.
- 2016 Oct;49(5):288-294.
- doi: 10.4163/jnh.2016.49.5.288
PURPOSE: The aim of this work was to investigate the beneficial effects of rhamnazin against inflammation, reactive oxygen species (ROS)/reactive nitrogen species (RNS), and anti-oxidative activity in murine macrophage RAW264.7... -
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- Leukotriene related gene polymorphisms in ASA-intolerant asthma: an association of 5-lipoxygenase haplotype
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Choi JH, Park HS, Shin SS, Oh HB, Lee JH, Suh YJ, Park CS, Shin HD
- KMID: 2178419
- J Asthma Allergy Clin Immunol.
- 2003 Dec;23(4):800-809.
BACKGROUND AND OBJECTIVES: A recent study has demonstrated a possible involvement of leukotriene C4 synthase (LTC4S) gene polymorphism in ASA-intolerant asthma (AIA) in a Polish population, while no significances were... -
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- Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK
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Ha YJ, Seul HJ, Lee JR
- KMID: 1097267
- Exp Mol Med.
- 2011 Feb;43(2):101-110.
- doi: 10.3858/emm.2011.43.2.012
Previously, we reported that CD40-induced production of reactive oxygen species (ROS) by NADPH oxidase requires the TNF receptor-associated factor (TRAF) 3, as well as the activities of phosphatidylinositol 3-kinase (PI3K)... -
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- The Signaling Pathway of G-protein Rac and Eicosanoid Synthesis by Titanium Particles
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Lee SS, Her JY, Woo CH, Kim JH, Chang JD
- KMID: 2105760
- J Korean Orthop Assoc.
- 2001 Aug;36(4):317-325.
PURPOSE: In order to understand the intracellular signaling pathway involving the c-fos gene expression that is caused by Titanium-particles, we analyzed the involvement of Rac, cytosolic phospholipase A2, and eicosanoids... -
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- Benzoxazole Derivative B-98 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis and the Change of T Cell Profiles in Acute Murine Colitis Model
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Song EM, Jung SA, Lee JS, Kim SE, Shim KN, Jung HK, Yoo K, Park HY
- KMID: 1711277
- Korean J Gastroenterol.
- 2013 Jul;62(1):33-41.
- doi: 10.4166/kjg.2013.62.1.33
BACKGROUND/AIMS: The unique role of enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it a therapeutic target for inflammatory bowel disease (IBD). The aim of this study was to... -
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- The Effect of Montelukast in the Treatment of Atopic Dermatitis through the SCORAD Index
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Lee YK, Kim YH, Kim KH, Lee CW
- KMID: 2087907
- Korean J Dermatol.
- 2008 Jan;46(1):34-39.
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease, with genetic and environmental background. The pathogenesis is complex, and although the dermatitis fades during childhood in most cases,... -
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- Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels
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Li X, Lu Y, Jin Y, Son JK, Lee SH, Chang HW
- KMID: 2048327
- Biomol Ther.
- 2014 Jan;22(1):27-34.
Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its... -
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- Association of Polymorphism in the Promoter Area of Leukotriene C4 Synthase Gene with Aspirin-Intolerant Asthma
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- KMID: 1850196
- Korean J Asthma Allergy Clin Immunol.
- 2006 Jun;26(2):115-121.
BACKGROUND: The 5-lipoxygenase, 5-lipoxygenase associated protein and leukotriene C4 (LTC4) synthase are enzymes involved in the synthesis of cysteinyl leukotrienes which are known to be important lipid mediators for the... -
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- Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model
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Lim JH, Kim JH, Kim N, Lee BH, Seo PJ, Kang JM, Jo SY, Park JH, Nam RH, Chang H, Kwon JW, Lee DH
- KMID: 1774528
- Gut Liver.
- 2014 Jan;8(1):49-57.
BACKGROUND/AIMS: The major compounds of Cochinchina momordica seed extract (SK-MS10) include momordica saponins. We report that the gastroprotective effect of SK-MS10 in an ethanol-induced gastric damage rat model is mediated... -
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- Post-treatment Effects of Erythropoietin and Nordihydroguaiaretic Acid on Recovery from Cisplatin-induced Acute Renal Failure in the Rat
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Lee DW, Kwak IS, Lee SB, Song SH, Seong EY, Yang BY, Lee MY, Sol MY
- KMID: 1778158
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S170-S175.
- doi: 10.3346/jkms.2009.24.S1.S170
5-Lipoxygenase inhibitor and human recombinant erythropoietin might accelerate renal recovery in cisplatin-induced acute renal failure rats. Male Sprague-Dawley rats were randomized into four groups: 1) normal controls; 2) Cisplatin group-cisplatin... -
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- Leukotriene-related Gene Polymorphisms in Patients with Aspirin-intolerant Urticaria and Aspirin-intolerant Asthma: Differing Contributions of ALOX5 Polymorphism in Korean Population
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Kim SH, Choi JH, Holloway J, Suh CH, Nahm DH, Ha EH, Park CS, Park HS
- KMID: 2157738
- J Korean Med Sci.
- 2005 Dec;20(6):926-931.
- doi: 10.3346/jkms.2005.20.6.926
The pathogenesis of aspirin (acetylsalicylic acid, ASA)-intolerant urticaria (AIU) is still poorly understood but it has recently been suggested that it is associated with the overproduction of leukotriene (LT). This... -
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- Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity
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Shen M, Zhang L, Lee KM, Vermeulen , Hosgood HD, Li G, Yin S, Rothman N, Chanock S, Smith MT, Lan Q
- KMID: 1107379
- Exp Mol Med.
- 2011 Jun;43(6):374-378.
- doi: 10.3858/emm.2011.43.6.041
Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity... -
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