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Transforming growth factor-beta1 protein, proliferation and apoptosis of oval cells in acetylaminofluorene-induced rat liver regeneration

Park DY, Suh KS

Administering of 2-acetylaminofluorene (2-AAF) before a two-thirds partial hepatectomy (PHx) results in suppression of hepatocyte proliferation and stimulation of oval cell proliferation. The objectives of this study was to examine...
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Nitric oxide mediates epinephrine-induced apoptotic cell death of trabecular meshwork cells in vitro

Kim JW, Kim SK, Kim KH

To evaluate the effect of epinephrine on the cellular proliferation and production of nitric oxide (NO) in trabecular meshwork (TM) cells, cultured porcine TM cells were exposed to epinephrine at...
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Regeneration of kidney tissue using in vitro cultured fetal kidney cells

Kim SS, Gwak SJ, Han J, Park MH, Song KW, Kim BS

Transplanting fetal kidney cells (FKCs) can regenerate kidney. This requires in vitro expansion in cell number to acquire enough cells for transplantation. However, FKCs may change their cellular characteristics during...
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Targeted Molecular Imaging

Kim EE

Molecular imaging aims to visualize the cellular and molecular processes occurring in living tissues, and for the imaging of specific molecules in vivo, the development of reporter probes and dedicated...
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Oxidation-dependent effects of oxidized LDL: proliferation or cell death

Han CY, Kim Pak YM

  • KMID: 1029922
  • Exp Mol Med.
  • 1999 Dec;31(4):165-173.
Oxidized low-density lipoprotein (oxLDL) induces a wide range of cellular responses to produce atherosclerotic lesion, but key factors determining the response are not understood. In this study, purified...
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NF-kappa B activation following optic nerve transection

Choi JS, Kim-Yoon S, Joo CK

In order to elucidate in vivo neuronal cell death in the retina, and involvement of NF-kappa B in this process, we studied the degeneration of retinal ganglion cells (RGCs) and...
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Biological characteristics of Chinese hamster ovary cells transfected with bovine Prnp

Kang SG, Lee DY, Kang ML, Yoo HS

A normal prion protein (PrPc) is converted to a proteaseresistant isoform by an apparent self-propagating activity in transmissible spongiform encephalopathy, a neurodegenerative disease. The cDNA encoding open reading frame (ORF)...
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Apoptosis in dilated cardiomyopathy

Hong BK, Kwon HM, Byun KH, Kim D, Choi EY, Kang TS, Kang SM, Chun KJ, Jang Y, Kim HS

  • KMID: 759491
  • Korean J Intern Med.
  • 2000 Jan;15(1):56-64.
OBJECTIVE: Cardiomyopathy, a popular diagnosis that always obscures more than it reveals, nevertheless has several characteristic histological features. These prominently include widespread focal myocardial fibrosis and associated hypertrophy of surviving...
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Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-alpha, and JNK

Lew BL, Cho Y, Kim J, Sim WY, Kim NI

Ceramides are the main lipids in the stratum corneum and are generated during cellular stress and apoptosis by de novo synthesis or by the action of sphingomyelinase. In addition, they...
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Altered Cellular Kinetics in Growth Plate according to Alterations in Weight Bearing

Park H, Kong SY, Kim HW, Yang IH

PURPOSE: To examine the effects of change in weight bearing on the growth plate metabolism, a simulated animal model of weightlessness was introduced and the chondrocytes' cellular kinetics was evaluated. MATERIALS...
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Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3

Sung HJ, Choi SM, Yoon YS, An KS

  • KMID: 1029923
  • Exp Mol Med.
  • 1999 Dec;31(4):174-178.
Tanshinone II-A is a derivative of phenanthrene-quinone isolated from Salvia miltiorrhiza BUNGE, a traditional herbal medicine that is known to induce antiinflammatory, anti-oxidative and cytotoxic activity. We have...
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Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion injury

Lee MJ, Kwak YK, You KR, Lee BH, Kim DG

Oxidative stress is critical for causing cardiac injuries during ischemia-reperfusion (IR), yet the molecular mechanism for this remains unclear. In the present study, we observe that hypoxia and reoxygenation, a...
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Increased phosphorylation of c-Jun NH (2)-terminal protein kinase in the sciatic nerves of Lewis rats with experimental autoimmune neuritis

Ahn M, Shin T

The phosphorylation of c-Jun NH (2)-terminal protein kinase (JNK), one of the mitogen-activated protein kinases, was analyzed in the sciatic nerves of Lewis rats with experimental autoimmune neuritis (EAN). Western...
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Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells

Choi JH, Kim JS, Kim YC, Kim YS, Chung NH, Cho MH

  • KMID: 1094683
  • J Vet Sci.
  • 2004 Mar;5(1):11-18.
Accurate estimation of the exposure-response relationship between ambient urban particulate matters (PM) and public health is important for regulatory perspective of ambient urban particulate matters (PM). Ambient PM contains various...
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IL-10 Mediates Rosiglitazone-Induced Kidney Protection in Cisplatin Nephrotoxicity

Kim MG, Yang HN, Kim HW, Jo SK, Cho WY, Kim HK

Cisplatin, a major anti-neoplastic drug, is known to be nephrotoxic and inflammation-inducing. A peroxisome proliferator-activated receptor gamma agonist, regulating lipid metabolism, has known to have anti-inflammatory effect, but the protection...
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