- Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-XL
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Woo KM, Kim HM, Ko JS
- KMID: 755205
- Exp Mol Med.
- 2002 Nov;34(5):340-346.
Macrophage colony-stimulating factor (M-CSF) is known as one of the factors essential for osteoclast development. In the present study, we examined effects of M-CSF on the apoptotic pathway of osteoclast... -
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- Nickel (II)-induced apoptosis and G2/M enrichment
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Lee SH, Kim DK, Seo YR, Woo KM, Kim CS, Cho MH
- KMID: 1109301
- Exp Mol Med.
- 1998 Sep;30(3):171-176.
Treatment with certain DNA-damaging agents induce a complex cellular response comprising pertubation of cell cycle progression and/or apoptosis on proliferating mammalian cells. Our studies were focused on the cellular effects of nickel (II)... -
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- The effect of cyclophosphamide on Fas-mediated apoptosis
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Lee JH, Park JH, Yang MH
- KMID: 1038387
- J Korean Med Sci.
- 1997 Jun;12(3):185-189.
- doi: 10.3346/jkms.1997.12.3.185
Fas is a cell surface protein that can mediate apoptosis and belongs to the tumor necrosis factor (TNF) receptor family. Anti-Fas antibody induces apoptotic cell death in... -
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- Kinetin inhibits apoptosis of aging spleen cells induced by D-galactose in rats
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Li M, Ouyang W, Wu X, Zheng Y, Wei Y, An L
- KMID: 2155618
- J Vet Sci.
- 2014 Sep;15(3):353-359.
- doi: 10.4142/jvs.2014.15.3.353
Kinetin (Kn) is a cytokinin growth factor that exerts several anti-aging and antioxidant effects on cells and organs. To investigate the mechanism underlying apoptotic events in aging cells induced by... -
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- Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells
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Lee JE, Sohn JW, Lee JH, Lee KC, Son CS, Tockgo YC
- KMID: 927133
- Exp Mol Med.
- 2000 Mar;32(1):42-46.
Numerous types of cells have been shown to undergo apoptosis when exposed to oxidant agent such as hydrogen peroxide. In order to understand the functional relationship between the anti- and... -
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- Fluoxetine Protects against Big Endothelin-1 Induced Anti-Apoptosis by Rescuing Kv1.5 Channels in Human Pulmonary Arterial Smooth Muscle Cells
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Dai F, Mao Z, Xia J, Zhu S, Wu Z
- KMID: 1716887
- Yonsei Med J.
- 2012 Jul;53(4):842-848.
- doi: 10.3349/ymj.2012.53.4.842
PURPOSE: Pulmonary Kv channels are thought to play a crucial role in the regulation of cell proliferation and apoptosis. Previous studies have shown that fluoxetine upregulated the expression of Kv1.5... -
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- Role of Ca2+ influx in the tert-butyl hydroperoxide-induced apoptosis of HepG2 human hepatoblastoma cellse
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Kim JA, Kang YS, Kim YO, Lee SH, Lee YS
- KMID: 1109296
- Exp Mol Med.
- 1998 Sep;30(3):137-144.
Oxidative stress appears to be implicated in the pathogenesis of various diseases including alcoholic liver injury. In this study we investigated the mechanism of apoptosis induced by tert-butyl hydroperoxide (TBHP) in HepG2... -
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- Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells
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Park BJ, Kim JH, Han JS, Jung PM
- KMID: 755043
- Exp Mol Med.
- 1999 Sep;31(3):142-150.
Ceramide, a product of sphingomyelin hydrolysis, is now recognized as an intracellular lipid messenger, which mediates the effects of extracellular agents on cellular growth, differentiation and apoptosis. Recently, ceramide has been implicated in... -
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- Withaferin A-Caused Production of Intracellular Reactive Oxygen Species Modulates Apoptosis via PI3K/Akt and JNKinase in Rabbit Articular Chondrocytes
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Yu SM, Kim SJ
- KMID: 2129597
- J Korean Med Sci.
- 2014 Aug;29(8):1042-1053.
- doi: 10.3346/jkms.2014.29.8.1042
Withaferin A (WFA) is known as a constituent of Ayurvedic medicinal plant, Withania somnifera, and has been used for thousands of years. Although WFA has been used for the treatment... -
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- Mitomycin C-induced apoptosis in cultured human Tenon's capsule fibroblasts
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Kim JW, Kim SK, Song IH, Kim IT
- KMID: 1081830
- Korean J Ophthalmol.
- 1999 Jun;13(1):7-15.
- doi: 10.3341/kjo.1999.13.1.7
To investigate the mitomycin C-induced apoptotic cell death of fibroblasts, the primarily cultured human Tenon's capsule fibroblasts were exposed to a clinically used dosage of 0.4 mg/ml of mitomycin C... -
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- Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
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Choi JH, Ahn KS, Kim JG, Hong YS
- KMID: 927130
- Exp Mol Med.
- 2000 Mar;32(1):23-28.
Cytotoxic effect of either cisplatin or p53 gene transfection of lung cancer cells may be different depending on the p53 status of cells. We investigated cytotoxic effects on the combined... -
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- Blockade of Oxidative Stress by Vitamin C Ameliorates Albuminuria and Renal Sclerosis in Experimental Diabetic Rats
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Lee EY, Lee MY, Hong SW, Chung CH, Hong SY
- KMID: 1122624
- Yonsei Med J.
- 2007 Oct;48(5):847-855.
- doi: 10.3349/ymj.2007.48.5.847
PURPOSE: Oxidative stress has been suggested to play a role as a common mediator of apoptosis and kidney damage in diabetes. However, it is uncertain whether the apoptosis occurs... -
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- Anti-apoptotic role of phospholipase D isozymes in the glutamate-induced cell death
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Kim KO, Lee KH, Kim YH, Park SK, Han JS
- KMID: 1088656
- Exp Mol Med.
- 2003 Feb;35(1):38-45.
Abstract Phospholipase D (PLD) plays an important role as an effector in a variety of physiological processes that reveal it to be a member of the signal transducing phospholipases. Recently,... -
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- Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells
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Yun BR, Lee MJ, Kim JH, Kim IH, Yu GR, Kim DG
- KMID: 994402
- Exp Mol Med.
- 2010 Nov;42(11):787-797.
- doi: 10.3858/emm.2010.42.11.082
Cholangiocarcinoma (CC) is a chemoresistant intrahepatic bile duct carcinoma with a poor prognosis. The aims of this study were to identify molecular pathways that enhance sesquiterpene lactone parthenolide (PTL)-induced anticancer... -
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- The relationship between cisplatin-induced apoptosis and p53, bcl-2 and bax expression in human lung cancer cells
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Han JY, Chung YJ, Park SW, Kim JS, Rhyu MG, Kim HK, Lee KS
- KMID: 759083
- Korean J Intern Med.
- 1999 Jan;14(1):42-52.
OBJECTIVES: Given the roles of bcl-2, bax and p53 in apoptosis, we investigated the effect of their expression on the response to cisplatin in order to understand the... -
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- Berberine Inhibited the Growth of Thyroid Cancer Cell Lines 8505C and TPC1
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Park KS, Kim JB, Bae J, Park SY, Jee HG, Lee KE, Youn YK
- KMID: 1120201
- Yonsei Med J.
- 2012 Mar;53(2):346-351.
- doi: 10.3349/ymj.2012.53.2.346
PURPOSE: Thyroid cancer is the most common malignancy in Korean females and can be treated with good prognosis. However, drugs to treat aggressive types of thyroid cancer such as poorly... -
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- Direct and Indirect Effects of Androgens on Survival of Hematopoietic Progenitor Cells In Vitro
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Kim SW, Hwang JH, Cheon JM, Park NS, Park SE, Park SJ, Yun HJ, Kim S, Jo DY
- KMID: 1778498
- J Korean Med Sci.
- 2005 Jun;20(3):409-416.
- doi: 10.3346/jkms.2005.20.3.409
Androgens remain a common treatment for certain type of anemia, based upon its myelostimulating effects; however, it has not been established whether androgens affect apoptosis of hematopoietic progenitor cells (HPCs).... -
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- Induction of apoptosis in colon cancer cells by nonsteroidal anti-inflammatory drugs
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Hong SP, Ha SH, Park IS, Kim WH
- KMID: 711560
- Yonsei Med J.
- 1998 Aug;39(4):287-295.
- doi: 10.3349/ymj.1998.39.4.287
Epidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the incidence of colon cancer. In addition, NSAIDs reduce the number and size of polyps in patients with familial adenomatous... -
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- D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells
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Kwon KB, Park EK, Ryu DG, Park BH
- KMID: 1093595
- Exp Mol Med.
- 2002 Mar;34(1):32-37.
Daunorubicin, an anti-cancer drug, is known to induce apoptosis in HL-60 cells in a dose-dependent manner through the activation of caspase-3 (CPP32). Caspase-3 selective inhibitor, Ac-DEVD-CHO, prevented both the activation... -
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- TGF-beta1 inhibition of apoptosis through the transcriptional up-regulation of Bcl-X(L) in human monocytic leukemia U937 cells
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Lee JH, Park BJ, Park JH, Yang MH, Chi SG
- KMID: 755040
- Exp Mol Med.
- 1999 Sep;31(3):126-133.
To characterize the TGF-beta1 response of monocytic leukemia cells, we analyzed the effects of TGF-beta1 on cell proliferation, differentiation, and apoptosis of human monoblastic U937 cells. Treatment of cells with TGF-beta1 in... -
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