- Quantitative expression and localization of cysteine and aspartic proteases in human abdominal aortic aneurysms
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Lohoefer F, Reeps C, Lipp C, Rudelius M, Haertl F, Matevossian E, Zernecke A, Eckstein H, Pelisek J
- KMID: 2155360
- Exp Mol Med.
- 2014 May;46(5):e95.
- doi: 10.1038/emm.2014.20
Cysteine and aspartic proteases possess high elastolytic activity and might contribute to the degradation of the abdominal aortic aneurysm (AAA) wall. The aim of this study was to analyze, in... -
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- Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice
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Shin W, Berkowitz , Ryoo S
- KMID: 1506223
- Exp Mol Med.
- 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that... -
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- Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions
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Hong BK, Kwon HM, Lee BK, Kim D, Kim IJ, Kang SM, Jang Y, Cho SH, Kim HK, Jang BC, Cho SY, Kim HS, Kim MS, Kwon HC, Lee N
- KMID: 1060276
- Yonsei Med J.
- 2000 Feb;41(1):82-88.
- doi: 10.3349/ymj.2000.41.1.82
Inflammation appears to have a major role in the development of atherosclerosis. Cyclooxygenase-2 (COX-2) is involved in the inflammatory response via the generation of prostanoids that, in turn, are involved... -
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