- Inhibitory Effect of Ginsenosides Rh1 and Rg2 on Oxidative Stress in LPS-Stimulated RAW 264.7 Cells
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Jin Y, Baek N, Back S, Myung CS, Heo KS
- KMID: 2452068
- J Bacteriol Virol.
- 2018 Dec;48(4):156-165.
- doi: 10.4167/jbv.2018.48.4.156
Minor ginsenosides Rh1 and Rg2 were isolated from Korean red ginseng and reported to have various biological effects on anti-inflammatory and anti-stress activities. However, the effects of Rh1 and Rg2... -
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- Ethanol Extract of Cirsium japonicum var. ussuriense Kitamura Exhibits the Activation of Nuclear Factor Erythroid 2-Related Factor 2-dependent Antioxidant Response Element and Protects Human Keratinocyte HaCaT Cells Against Oxidative DNA Damage
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Yoo OK, Choi BY, Park JO, Lee JW, Park BK, Joo CG, Heo HJ, Keum YS
- KMID: 2161526
- J Cancer Prev.
- 2016 Mar;21(1):66-72.
- doi: 10.15430/JCP.2016.21.1.66
Keratinocytes are constantly exposed to extracellular insults, such as ultraviolet B, toxic chemicals and mechanical stress, all of which can facilitate the aging of keratinocytes via the generation of intracellular... -
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- Protopanaxatriol Ginsenoside Rh1 Upregulates Phase II Antioxidant Enzyme Gene Expression in Rat Primary Astrocytes: Involvement of MAP Kinases and Nrf2/ARE Signaling
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Jung JS, Lee SY, Kim DH, Kim HS
- KMID: 2170538
- Biomol Ther.
- 2016 Jan;24(1):33-39.
- doi: 10.4062/biomolther.2015.129
Oxidative stress activates several intracellular signaling cascades that may have deleterious effects on neuronal cell survival. Thus, controlling oxidative stress has been suggested as an important strategy for prevention and/or... -
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- 4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
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Yoo OK, Keum YS
- KMID: 2455093
- Biomol Ther.
- 2019 Jul;27(4):381-385.
- doi: 10.4062/biomolther.2018.232
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage... -
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- Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells
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Kim MK, Park HJ, Kim SR, Choi YK, Bae SK, Bae MK
- KMID: 2285575
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):327-334.
- doi: 10.4196/kjpp.2015.19.4.327
The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1... -
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- Arctigenin Increases Hemeoxygenase-1 Gene Expression by Modulating PI3K/AKT Signaling Pathway in Rat Primary Astrocytes
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Jeong YH, Park JS, Kim DH, Kim HS
- KMID: 2170590
- Biomol Ther.
- 2014 Nov;22(6):497-502.
- doi: 10.4062/biomolther.2014.121
In the present study, we found that the natural compound arctigenin inhibited hydrogen peroxide-induced reactive oxygen species (ROS) production in rat primary astrocytes. Since hemeoxygenase-1 (HO-1) plays a critical role... -
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- Protection by Chrysanthemum zawadskii extract from liver damage of mice caused by carbon tetrachloride is maybe mediated by modulation of QR activity
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Seo JY, Lim SS, Park J, Lim JS, Kim HJ, Kang HJ, Yoon Park , Kim JS
- KMID: 2313430
- Nutr Res Pract.
- 2010 Apr;4(2):93-98.
Our previous study demonstrated that methanolic extract of Chrysanthemum zawadskii Herbich var. latilobum Kitamura (Compositae) has the potential to induce detoxifying enzymes such as NAD(P)H:(quinone acceptor) oxidoreductase 1 (EC 1.6.99.2)... -
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- Ajoene, a Major Organosulfide Found in Crushed Garlic, Induces NAD(P)H:quinone Oxidoreductase Expression Through Nuclear Factor E2-related Factor-2 Activation in Human Breast Epithelial Cells
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Cho SJ, Ryu JH, Surh YJ
- KMID: 2454670
- J Cancer Prev.
- 2019 Jun;24(2):112-122.
- doi: 10.15430/JCP.2019.24.2.112
BACKGROUND: NAD(P)H:quinone oxidoreductase-1 (NQO1) is a widely-distributed flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes. This reduces quinone levels and thereby minimizes... -
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