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Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue

Yasuda M, Kawabata J, Akieda-Asai S, Nasu T, Date Y

Guanylyl cyclase C (GC-C) is a member of a family of enzymes that metabolize GTP to cGMP and was first identified as a receptor for heat-stable enterotoxin. Guanylin (GNY) has...
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Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats

Kim B, Choi KM, Yim HS, Park HT, Yim JH, Lee MG

PURPOSE: Ascorbic acid has been reported to have an adipogenic effect on 3T3-L1 preadipocytes, while evidence also suggests that ascorbic acid reduces body weight in humans. In this study, we...
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Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes

Jeon MJ, Leem J, Ko MS, Jang JE, Park HS, Kim HS, Kim M, Kim EH, Yoo HJ, Lee CH, Park IS, Lee KU, Koh EH

  • KMID: 1389736
  • Exp Mol Med.
  • 2012 Sep;44(9):562-570.
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are considered the key determinants of insulin resistance. Impaired mitochondrial function in obese animals was shown to induce the ER stress response, resulting...
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BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity

Kim DH, Do MS

Obesity is recognized as a chronic low-grade inflammatory state due to adipose tissue expansion being accompanied by an increase in the production of proinflammatory adipokines. Our group is the first...
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