- The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
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Lee IK
- KMID: 2280687
- Diabetes Metab J.
- 2014 Jun;38(3):181-186.
- doi: 10.4093/dmj.2014.38.3.181
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient... -
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- The Role of N-Acetyl Transferases on Isoniazid Resistance from Mycobacterium tuberculosis and Human: An In Silico Approach
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Unissa AN, Sukumar S, Hanna LE
- KMID: 2385040
- Tuberc Respir Dis.
- 2017 Jul;80(3):255-264.
- doi: 10.4046/trd.2017.80.3.255
BACKGROUND: N-acetyl transferase (NAT) inactivates the pro-drug isoniazid (INH) to N-acetyl INH through a process of acetylation, and confers low-level resistance to INH in Mycobacterium tuberculosis (MTB). Similar to NAT... -
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- Effects of medicinal herb water extracts on expression of hepatic glucokinase, pyruvate dehydrogenase and acetyl-CoA carboxylase mRNA
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Kim HS, Kim TW, Kim DJ, Lee JS, Choe M
- KMID: 2269389
- Korean J Nutr.
- 2013 Apr;46(2):119-125.
- doi: 10.4163/kjn.2013.46.2.119
We studied the anti-diabetic effects of medicinal herb water extracts on expression of hepatic glucokinase (GCK), pyruvate dehydrogenase (PDH), and acetyl-CoA carboxylase (ACC) mRNA. The medicinal herbs used for experiments... -
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- Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
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Koo SH
- KMID: 1705200
- Clin Mol Hepatol.
- 2013 Sep;19(3):210-215.
- doi: 10.3350/cmh.2013.19.3.210
Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the... -
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- Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
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Jeoung NH
- KMID: 2281531
- Diabetes Metab J.
- 2015 Jun;39(3):188-197.
- doi: 10.4093/dmj.2015.39.3.188
Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major... -
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- Overexpression of AMPKalpha1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats
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Seo E, Park EJ, Joe Y, Kang S, Kim MS, Hong SH, Park MK, Kim DK, Koh H, Lee HJ
- KMID: 2285380
- Korean J Physiol Pharmacol.
- 2009 Dec;13(6):449-454.
- doi: 10.4196/kjpp.2009.13.6.449
5'-AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic (alpha) and two regulatory (beta and gamma) subunits. Two isoforms are known for catalytic subunit (alpha1, alpha2) and... -
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- High maysin corn silk extract reduces body weight and fat deposition in C57BL/6J mice fed high-fat diets
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Lee EY, Kim SL, Kang HJ, Kim MH, Ha AW, Kim WK
- KMID: 2359613
- Nutr Res Pract.
- 2016 Dec;10(6):575-582.
- doi: 10.4162/nrp.2016.10.6.575
BACKGROUNG/OBJECTIVES: The study was performed to investigate the effects and mechanisms of action of high maysin corn silk extract on body weight and fat deposition in experimental animals. MATERIALS/METHODS: A total... -
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