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An Experimental Animal Model of Fulminant Hepatic Failure in Pigs

Lee KU, Zheng LX, Cho YB, Kim KH, Ha J, Suh KS, Jung SE

The objective of this study was to develop an experimental animal model of fulminant hepatic failure to test the efficacy of the bioartificial liver system. The portal vein and the...
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Neuropathic Pain Model of Peripheral Neuropathies Mediated by Mutations of Glycyl-tRNA Synthetase

Lee SJ, Seo AJ, Park BS, Jo HW, Huh Y

Charcot-Marie-Tooth disease (CMT) is the most common inherited motor and sensory neuropathy. Previous studies have found that, according to CMT patients, neuropathic pain is an occasional symptom of CMT. However,...
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Time Sequence of Airway Remodeling in a Mouse Model of Chronic Asthma: the Relation with Airway Hyperresponsiveness

Kim SJ, Kim CH, Ahn JH, Kim MS, Kim SC, Lee SY, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS, Park SH

During the course of establishing an animal model of chronic asthma, we tried to elucidate the time sequence of airway hyperresponsiveness (AHR), airway inflammation, airway remodeling, and associated cytokines. Seven-week-old...
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Animal Models for Echinostoma malayanum Infection: Worm Recovery and Some Pathology

Songsri J, Aukkanimart R, Boonmars T, Ratanasuwan P, Laummaunwai P, Sriraj P, Sripan P

Echinostomes are intestinal trematodes that infect a wide range of vertebrate hosts, including humans, in their adult stage and also parasitize numerous invertebrate and cold-blooded vertebrate hosts in their larval...
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Establishment of hydrochloric acid/lipopolysaccharide-induced pelvic inflammatory disease model

Oh Y, Lee J, Kim HC, Hahn TW, Yoon BI, Han JH, Kwon YS, Park JJ, Koo DB, Rhee KJ, Jung BD

Pelvic inflammatory disease (PID), which is one of the most problematic complications experienced by women with sexually transmitted diseases, frequently causes secondary infections after reproductive abnormalities in veterinary animals. Although...
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Experimental Toxocara cati Infection in Gerbils and Rats

Zibaei M, Sadjjadi S, Uga S

Mongolian gerbils and Wistar rats were inoculated orally with 240 and 2,500 Toxocara cati embryonated eggs, respectively, to evaluate the larval recovery in different tissues and organs, such as the...
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An experimental model of ischemia in rabbit hindlimb

Hong JH, Bahk YW, Suh JS, Kwak BK, Shim HJ, Kim JS, Kim HS, Moon YH, Kim SJ, Chung JW, Park JH

This study was performed to establish an experimental model of ischemia for the investigation of new treatment modality of limb-threatening ischemia. We produced ischemia in the hindlimbs of 8 New...
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Viscerotropic growth pattern of Leishmania tropica in BALB/c mice is suggestive of a murine model for human viscerotropic leishmaniasis

Mahmoudzadeh-Niknam H, Kiaei SS, Iravani D

Leishmania (L.) tropica is a causative agent of cutaneous leishmaniasis, and occasionally of visceral or viscerotropic leishmaniasis in humans. Murine models of Leishmania infection have been proven to be useful...
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Effects of Vitamin K2 on the Development of Osteopenia in Rats as the Models of Osteoporosis

Iwamoto J, Takeda T, Sato Y

Vitamin K2 is widely used for the treatment of osteoporosis in Japan. To understand the effects of vitamin K2 on bone mass and bone metabolism, we reviewed its effects on...
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Morphological study of surgically induced open neural tube defects in chick embryos--postoperative 24 hours

You H, Sim KB, Wang KC, Kim DG, Kim HJ

For the experimental study of neural tube defect (NTD), a surgical model has advantages over other models in a few aspects. It causes less functional derangement of cells and the...
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Establishment of a canine mammary gland tumor cell line and characterization of its miRNA expression

Osaki T, Sunden Y, Sugiyama A, Azuma K, Murahata Y, Tsuka T, Ito N, Imagawa T, Okamoto Y

Canine mammary gland tumors (CMGTs), which are the most common neoplasms in sexually intact female dogs, have been suggested as a model for studying human breast cancer because of several...
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Development of Advanced Atherosclerotic Plaque by Injection of Inflammatory Proteins in a Rabbit Iliac Artery Model

Kim JS, Lee SG, Oh J, Park S, Park SI, Hong SY, Kim S, Lee SH, Ko YG, Choi D, Hong MK, Jang Y

PURPOSE: Appropriate animal models of atherosclerotic plaque are crucial to investigating the pathophysiology of atherosclerosis, as well as for the evaluation of the efficacy and safety of vascular devices. We...
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The Decellularized Vascular Allograft as an Experimental Platform for Developing a Biocompatible Small-Diameter Graft Conduit in a Rat Surgical Model

Hwang SJ, Kim SW, Choo SJ, Lee BW, Im IR, Yun HJ, Lee SK, Song H, Cho WC, Lee JW

PURPOSE: The present study was aimed to assess the feasibility of using decellularized aortic allograft in a rat small animal surgical model for conducting small diameter vascular tissue engineering research. MATERIALS...
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Altered Renal Sodium Transporter Expression in an Animal Model of Type 2 Diabetes Mellitus

Oh YK, Joo KW, Lee JW, Jeon US, Lim CS, Han JS, Knepper MA, Na KY

Hemodynamic factors play an important role in the development and/or progression of diabetic nephropathy. We hypothesized that renal sodium transporter dysregulation might contribute to the hemodynamic alterations in diabetic nephropathy....
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A New Flow-Diverter (the FloWise): In-Vivo Evaluation in an Elastase-Induced Rabbit Aneurysm Model

Kim BM, Kim DJ, Kim DI

OBJECTIVE: We aimed to evaluate the efficacy and safety of a newly developed, partially retrievable flow-diverter (the FloWise) in an elastase-induced rabbit aneurysm model. MATERIALS AND METHODS: We developed a partially...
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Simulation of proliferative vitreoretinopathy in pigmented rabbits

Lee JS, Lee J

proliferative vitreoretinopathy (PVR) is the most common cause of failure in retinal reattachment surgery. Three different procedures were performed in 20 pigmented rabbits to devise a simple model to induce...
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Pyridoxine induced neuropathy by subcutaneous administration in dogs

Chung JY, Choi JH, Hwang CY, Youn HY

To construct a sensory neuropathy model, excess pyridoxine (150 mg/kg s.i.d.) was injected subcutaneously in dogs over a period of 7 days. During the administrations period, the dogs experienced body...
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Effects of Adipose-derived Stromal Cells and of their Extract on Wound Healing in a Mouse Model

Lim JS, Yoo G

In this study, the authors investigated the effects of adipose-derived stromal cells (ADSCs) and of their extract on wound healing. After creating wound healing splint model on the backs of...
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Cerebral energy metabolism following ESWL brain injury model and effects of cerebral protective drugs

Whang CJ, Kwon Y

The goal of this study was to introduce a new method inducing an experimental brain injury model using ESWL(Extracorporeal Shock Wave Lithotripsy) and to evaluate findings of localized lesions on...
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Establishment of a canine spinal cord injury model induced by epidural balloon compression

Lim JH, Jung CS, Byeon YE, Kim WH, Yoon JH, Kang KS, Kweon OK

A model that provides reproducible, submaximal yet sufficient spinal cord injury is needed to allow experiments leading to development of therapeutic techniques and prediction of clinical outcome to be conducted....
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