Korean J Pediatr Gastroenterol Nutr.
1999 Mar;2(1):40-45.
Seroepidemiology of Hepatitis A and Hepatitis B in Korean Children
- Affiliations
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- 1Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.
- 2Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
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PURPOSE: The aim of this study is to investigate the seroepidemiology of hepatitis A and hepatitis B in Korean children.
METHOD: 801 children aged 6 to 12 years were enrolled. IgG antibody to hepatitis A virus (anti-HAV), hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), and IgG antibody to HBc (anti-HBc) were measured by radioimmunoassay.
RESULTS
Of the 801 children, the seroprevalence of anti-HAV was 0%. Three (0.4%) were seropositive for HBsAg. The seroprevalence of anti-HBs was 61.8%. Two (0.4%) of 495 anti-HBs positive subjects were positive for anti-HBc. Of the 801 children, 658 (82.1%) had received hepatitis B vaccination.
CONCLUSIONS
Since natural anti-HAV is not acquired in the childhood, the outbreak of hepatitis A is possible in adolescents and young adults. The decrease in seroprevalence of HBsAg and the increase in seroprevalence of anti-HBs might result from hepatitis B vaccination program in childhood.
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