Korean J Clin Microbiol.  2007 Apr;10(1):59-69.

Antimicrobial Resistance of Clinically Important Bacteria Isolated from 12 Hospitals in Korea in 2005 and 2006

• Lee H
• Kim CK
• Lee J
• Lee SH
• Ahn JY
• Hong SG
• Park YJ
• Jeong SH
• Kim EC
• Lee WK
• Uh Y
• Shin JH
• Choi TY
• Kwak HS
• Lee K

Abstract

BACKGROUND: Emergence and spread of antimicrobial resistant bacteria make it difficult to treat infections. A rapid increase in antimicrobial-resistant bacteria has become a serious problem in many countries including Korea, and it is important to perform a nationwide study of antimicrobial resistance to obtain some basic data that will help solve these problems. The aim of this study was to determine the nationwide prevalence of resistance among frequently isolated bacterial pathogens in 2005 and 2006 in Korea.
METHODS
We collected routine susceptibility data for medically important bacterial pathogens from 12 university and general hospital laboratories in Korea from April to September in 2005 and from January to June in 2006. Collected data was analyzed by patient group.
RESULTS
The proportions of methicillin-resistant Staphylococcus aureus (MRSA) were 65% in 2005 and 72% in 2006, respectively. The resistance rates of Enterococcus faecium to vancomycin were 29% in 2005 and 24% in 2006. The non-susceptible rates of Streptococcus pneumoniae to penicillin were 68% in 2005 and 74% in 2006. The resistant rates of Escherichia coli and Klebsiella pneumoniae to the 3rd generation cephalosporin were 10~12% and 25~39%, respectively, in 2005 and 11~15% and 30~34% in 2006. In Citrobacter freundii, Enterobacter cloacae and Serratia marcescens, the resistance rates to 3rd generation cephalosporin were 23~31%, 32~34%, and 17~27%, respectively, in 2005 and 21~37%, 37~43%, and 13~31% in 2006. The resistance rates to imipenem and meropenem were 21% and 18%, respectively, in Pseudomonas aeruginosa and 18% and 25% in Acinetobacter baumannii in 2005; 29% and 20% in P. aeruginosa and 18% and 23% in A. baumannii in 2006. Cotrimoxazole and levofloxacin resistance rates of Stenotrophomonas maltophilia were 5% and 13%, respectively, in 2005 and 3% and 7% in 2006. There were no isolates resistant to 3rd generation cephalosporin and fluoroquinolone among non-typhoidal Salmonella in 2005.
CONCLUSION
Antimicrobial resistance of medically important bacteria is still a serious problem in Korea. To manage the problem, a continuous nationwide surveillance and diversified investigation and effort have become more important.

Keyword

MRSA; VRE; ESBL; Carbapenem; Antimicrobial resistance; Nationwide surveillance

MeSH Terms

Acinetobacter baumannii
Bacteria*
Citrobacter freundii
Enterobacter cloacae
Enterococcus faecium
Escherichia coli
Hospitals, General
Humans
Imipenem
Klebsiella pneumoniae
Korea*
Levofloxacin
Methicillin-Resistant Staphylococcus aureus
Penicillins
Prevalence
Pseudomonas aeruginosa
Salmonella
Serratia marcescens
Stenotrophomonas maltophilia
Streptococcus pneumoniae
Trimethoprim, Sulfamethoxazole Drug Combination
Vancomycin
Imipenem
Penicillins
Vancomycin