Korean J Dermatol.  1987 Oct;25(5):643-648.

Iatrogenic Subcutaneous Aspergillosis in a Patient with Lumbar Spondylitis Treated with Ketoconazole

• Kim DS
• Kim SH
• Kim SW

Abstract

We report herein s case of subcutaneous aspergillosis in a 41-year-old woman with lumbar spondylitis(L4~L5). The patient had received high doses of corticosteroids and broad-spectrum antibiotics and two times of operation due to lumbar problems. The diagnosis of Aspergillus fumigatus infection was established by the mycologic study of cultures from wound exudate and histopathologic examination of the second surgical specimens of subcutaneous soft tissue, which was assumed to be iatrogenically susceptible infection. Intravenous amphotericin B therapy was discontinued because of the immediste adverse effects. After twelve-week therapy of oral ketoconazole(400mg/day), open wound healed and spondylitis with neurologic signs eventually resolved. No evidence of recurrent infection was noted during six months of follow-up.

Keyword

Subcutaneous aspergillosis; Ketoconazole; Iatrogenic

MeSH Terms

Adrenal Cortex Hormones
Adult
Amphotericin B
Anti-Bacterial Agents
Aspergillosis*
Aspergillus fumigatus
Diagnosis
Exudates and Transudates
Female
Follow-Up Studies
Humans
Ketoconazole*
Neurologic Manifestations
Spondylitis*
Wounds and Injuries
Adrenal Cortex Hormones
Amphotericin B
Anti-Bacterial Agents
Ketoconazole